{"id":"W2083297080","doi":"10.1371/journal.pone.0044213","title":"DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Prevention of Organ Failure; St. Paul's Hospital; University of British Columbia","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; GlaxoSmithKline; Michael Smith Health Research BC; Canadian Lung Association; Asthma Foundation of Western Australia; Canadian Thoracic Society","keywords":"DNA methylation; Epigenetics; CpG site; Immunology; Methylation; Atopy; Peripheral blood mononuclear cell; Asthma; Bisulfite sequencing; Medicine; Epigenomics; Allergy; Gene; Gene expression; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242483,0.000138055,0.0001850586,0.000312637,0.000191138,0.0002473357,0.0001358358,0.0002604758,0.001969865],"category_scores_gemma":[0.0004475119,0.00009540245,0.0001244074,0.0003481431,0.0001564626,0.00007511142,0.0002000056,0.0002809128,0.0003612757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001488711,"about_ca_system_score_gemma":0.0001320035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001810516,"about_ca_topic_score_gemma":0.002482816,"domain_scores_codex":[0.9998201,0.0000230248,0.00001584814,0.00006109725,0.00005499002,0.00002502042],"domain_scores_gemma":[0.9998857,0.00003245949,0.0000224863,0.000008660763,0.00002756441,0.00002314401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001545715,0.000097204,0.4856141,0.0002660995,0.0001109094,0.0007144638,0.00133224,0.0003126033,0.4874179,0.0001107543,0.0007996183,0.02167832],"study_design_scores_gemma":[0.00002676438,0.0005537843,0.9485869,0.00002333265,0.00007754597,0.003067152,0.00074734,0.0003942081,0.0431413,0.0001079447,0.003261028,0.00001265635],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949345,0.0007423997,0.000577076,0.00005921215,0.000007612941,0.00002401139,0.002727263,0.00001844492,0.0009094917],"genre_scores_gemma":[0.9943191,0.0004276315,0.001161765,0.00009950997,0.000007787581,0.00005639599,0.003016902,0.000009211408,0.0009016431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001969865,"threshold_uncertainty_score":0.00658989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02336364144844705,"score_gpt":0.2460006331820629,"score_spread":0.2226369917336158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}