{"id":"W2083301700","doi":"10.1021/tx500184c","title":"Clozapine Promotes the Proliferation of Granulocyte Progenitors in the Bone Marrow Leading to Increased Granulopoiesis and Neutrophilia in Rats","year":2014,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Neutrophilia; Granulopoiesis; Bone marrow; Granulocyte; Granulocyte colony-stimulating factor; Myelopoiesis; Haematopoiesis; Medicine; Absolute neutrophil count; Progenitor cell; Internal medicine; Clozapine; Myeloperoxidase; Endocrinology; Leukocytosis; Immunology; Myeloid; Neutropenia; Biology; Toxicity; Inflammation; Chemotherapy; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001302849,0.0001072273,0.0001879262,0.0001317442,0.00004599205,0.00001618557,0.000225802,0.0001607553,0.000002727363],"category_scores_gemma":[0.0007961057,0.00006916643,0.00002752982,0.0003884506,0.000260813,0.000004389201,0.0001375691,0.0002438302,0.000001686603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002654821,"about_ca_system_score_gemma":0.00006120219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001172088,"about_ca_topic_score_gemma":0.000718121,"domain_scores_codex":[0.998386,0.0005251553,0.0002449454,0.0003061131,0.0001763107,0.0003615362],"domain_scores_gemma":[0.9994267,0.0001856735,0.00003160764,0.000242464,0.00005495953,0.00005860162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004349467,0.0003824139,0.03587159,0.00004310389,0.000009497518,0.000007806138,0.0002439454,0.000004269667,0.9555295,0.0001783635,0.0001348394,0.007159752],"study_design_scores_gemma":[0.001753838,0.0007518808,0.01239955,0.00004443216,0.000005597706,0.00001168671,0.0001236852,0.0001163148,0.9822768,0.001602438,0.0008111533,0.000102606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950293,0.0007550363,0.000003505753,0.003240284,0.00001455094,0.0008378861,0.000002886765,0.00000203073,0.000114557],"genre_scores_gemma":[0.9990849,0.0001651144,0.00009284785,0.0001747047,0.00005060309,0.0003879474,0.00002304401,0.000009706112,0.00001112513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02674735,"threshold_uncertainty_score":0.2820525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882295972918201,"score_gpt":0.331047767909486,"score_spread":0.3022248081803039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}