{"id":"W2083301700","doi":"10.1021/tx500184c","title":"Clozapine Promotes the Proliferation of Granulocyte Progenitors in the Bone Marrow Leading to Increased Granulopoiesis and Neutrophilia in Rats","year":2014,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Neutrophilia; Granulopoiesis; Bone marrow; Granulocyte; Granulocyte colony-stimulating factor; Myelopoiesis; Haematopoiesis; Medicine; Absolute neutrophil count; Progenitor cell; Internal medicine; Clozapine; Myeloperoxidase; Endocrinology; Leukocytosis; Immunology; Myeloid; Neutropenia; Biology; Toxicity; Inflammation; Chemotherapy; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001675332,0.0005513084,0.0003769518,0.0008761725,0.0001999582,0.0003028506,0.0002687971,0.0003733316,0.001340291],"category_scores_gemma":[0.0001917656,0.0002728293,0.0004286681,0.0002467805,0.0003800113,0.000192297,0.0002738485,0.001090262,0.0005665033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721559,"about_ca_system_score_gemma":0.0003871364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002359594,"about_ca_topic_score_gemma":0.004585065,"domain_scores_codex":[0.999822,0.00003789991,0.00001726349,0.00003051745,0.00004180452,0.0000505816],"domain_scores_gemma":[0.9997358,0.00003044105,0.00007307834,0.00003713042,0.00002587912,0.00009776698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001824918,0.0003621874,0.0004505425,0.00005059766,0.00001179641,0.0002558059,0.00008313979,0.00009010567,0.993665,0.0001237688,0.0001117261,0.002970341],"study_design_scores_gemma":[0.0001337421,0.0052734,0.006980542,0.00002078994,0.00005047574,0.0002902632,0.0001565218,0.0008251027,0.9834667,0.000115353,0.002669234,0.00001783909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950245,0.001449114,0.001320883,0.0001856668,0.00004377053,0.00003906155,0.0004836067,0.0001699915,0.001283355],"genre_scores_gemma":[0.9911242,0.001635486,0.001976847,0.0001105995,0.00002159361,0.00007074872,0.0004242507,0.0000311818,0.004605229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359594,"threshold_uncertainty_score":0.00469166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882295972918201,"score_gpt":0.331047767909486,"score_spread":0.3022248081803039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}