{"id":"W2083308747","doi":"10.1038/35017574","title":"Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation","year":2000,"lang":"en","type":"article","venue":"Nature","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1387,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"National Heart, Lung, and Blood Institute; James S. McDonnell Foundation","keywords":"GSK-3; GSK3B; Biology; Kinase; Transactivation; Glycogen synthase; Wnt signaling pathway; Cell biology; NFKB1; Transcription factor; Tumor necrosis factor alpha; Signal transduction; Gene knockdown; Molecular biology; Phosphorylation; Gene; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002766607,0.0004271511,0.0003043105,0.0003945068,0.0003154369,0.0006528738,0.0002921461,0.0003305316,0.001930149],"category_scores_gemma":[0.000222747,0.0002922428,0.0004310599,0.0002225685,0.0003468113,0.0003790167,0.0003484866,0.0005129828,0.0008477197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007910633,"about_ca_system_score_gemma":0.0006611972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001122475,"about_ca_topic_score_gemma":0.002619233,"domain_scores_codex":[0.9997814,0.00002360824,0.00002409463,0.00003368135,0.00005839341,0.00007878823],"domain_scores_gemma":[0.9997475,0.00002599013,0.00006173036,0.00004047477,0.00002821687,0.00009608993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002996714,0.00002210505,0.0003434987,0.00004262426,0.000006016257,0.000182706,0.000009464286,0.00003024701,0.9977809,0.0003508907,0.00008563103,0.000846353],"study_design_scores_gemma":[0.00009265145,0.0002499019,0.03150002,0.00002856644,0.0000301256,0.002007275,0.0001071365,0.0007004168,0.9595927,0.0008775698,0.004801178,0.000012478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982415,0.008701352,0.003280271,0.0006261831,0.0001126448,0.00002818319,0.001140048,0.000276217,0.003420005],"genre_scores_gemma":[0.993233,0.001490195,0.001569719,0.00009395403,0.00001324617,0.00003663732,0.0008627312,0.00002356935,0.002676855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930149,"threshold_uncertainty_score":0.006456971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009298162311896384,"score_gpt":0.2566723414890745,"score_spread":0.2473741791771781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}