{"id":"W2083322686","doi":"10.1038/nrm2789","title":"35 years later, mRNA caps still matter","year":2009,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Messenger RNA; Biology; Computational biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003675589,0.0007863588,0.001892639,0.0001680961,0.00005190632,0.00003988618,0.0009093783,0.002707405,0.0001866867],"category_scores_gemma":[0.0000498264,0.0006197797,0.001262583,0.0002985106,0.0001132705,0.000003407423,0.0001854158,0.001135201,0.0007990152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006221493,"about_ca_system_score_gemma":0.0002181299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004412438,"about_ca_topic_score_gemma":0.000002940957,"domain_scores_codex":[0.9964641,0.0006624383,0.0009249282,0.001238238,0.0001252964,0.0005849422],"domain_scores_gemma":[0.9975278,0.00001479386,0.0006598355,0.001552449,0.00007743803,0.0001677069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004729259,0.00005914868,0.000002803166,0.00209978,0.0001035055,0.00001913592,0.000003615392,5.076682e-7,0.004757193,0.00004943576,0.01798965,0.9749105],"study_design_scores_gemma":[0.0001688917,0.0001178533,0.000003813977,0.001098082,0.0004474351,0.00004272453,6.314003e-7,2.256413e-7,0.0004138365,0.0000317094,0.9970103,0.0006645167],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003930026,0.9919676,0.000181316,0.00003233775,0.0004944233,0.001265192,0.0001133845,0.00001835324,0.005888081],"genre_scores_gemma":[0.0001160951,0.9916218,0.000855293,0.001744161,0.0004628399,0.0002445242,0.002555875,0.0001073579,0.002292064],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9790207,"threshold_uncertainty_score":0.999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487178704546348,"score_gpt":0.3152114294062243,"score_spread":0.3003396423607608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}