{"id":"W2083365324","doi":"10.1182/blood-2012-03-414359","title":"An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; University of Alberta; University of Calgary; University of Toronto","funders":"National Cancer Institute","keywords":"Carfilzomib; Bortezomib; Medicine; Multiple myeloma; Nausea; Proteasome inhibitor; Refractory (planetary science); Internal medicine; Adverse effect; Cohort; Clinical endpoint; Oncology; Surgery; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003257446,0.0003874175,0.0007495426,0.0003065002,0.0001249532,0.00005256225,0.0002734671,0.0001302373,0.00009023702],"category_scores_gemma":[0.0003414075,0.0002739115,0.00002918004,0.0004056817,0.0001230502,0.0005911626,0.0002087953,0.0002902472,0.00001162593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001730617,"about_ca_system_score_gemma":0.0001397571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008272829,"about_ca_topic_score_gemma":0.0005965236,"domain_scores_codex":[0.9970594,0.0002790746,0.0005874318,0.0005917274,0.000727265,0.0007550826],"domain_scores_gemma":[0.997807,0.0001932328,0.0002601359,0.0007711776,0.0002461528,0.0007222699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009041026,0.2563842,0.7029325,0.00007519215,0.0004593821,0.0002885546,0.002609105,4.367743e-7,0.01705194,0.000002038096,0.00003407655,0.01112163],"study_design_scores_gemma":[0.2255942,0.07434119,0.6876617,0.0002462444,0.0004783328,0.00002878328,0.001827463,0.00006850564,0.009176645,0.000001839411,0.0002216238,0.0003535286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955924,0.0003090985,0.000005179988,0.00002215845,0.00007948281,0.003459473,0.0001003021,0.00004860994,0.0003833255],"genre_scores_gemma":[0.9977781,0.00001961033,0.001441488,0.00005189058,0.00007754861,0.0002001538,0.0002213612,0.00007817519,0.0001317044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2165531,"threshold_uncertainty_score":0.9999713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06713614919153943,"score_gpt":0.3382739908904565,"score_spread":0.271137841698917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}