{"id":"W2083371314","doi":"10.1038/sj.ijo.0802554","title":"Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1","year":2004,"lang":"en","type":"article","venue":"International Journal of Obesity","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"P70-S6 Kinase 1; PI3K/AKT/mTOR pathway; Protein kinase B; Adipogenesis; Insulin receptor; Phosphorylation; IRS1; Insulin receptor substrate; Cell biology; Endocrinology; Biology; Insulin; Internal medicine; Chemistry; Signal transduction; Cancer research; Adipose tissue; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004310821,0.0001195349,0.0002038129,0.0001035713,0.00002514288,0.00001196431,0.0001559302,0.0001121568,0.00002053936],"category_scores_gemma":[0.0001747231,0.0001118572,0.0001275553,0.0000600871,0.00007201543,0.00001856993,0.00004218741,0.0001078579,0.000001035386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007740112,"about_ca_system_score_gemma":0.0000886007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003666405,"about_ca_topic_score_gemma":0.000003300881,"domain_scores_codex":[0.998879,0.00006652098,0.0004253835,0.0001492391,0.0003907696,0.00008906954],"domain_scores_gemma":[0.9988195,0.00004962151,0.0005273986,0.0000961873,0.0004483504,0.00005889007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001153067,0.0001919764,0.01037894,0.00002643259,0.0001654954,0.00001056265,0.00004568232,0.002009931,0.9833072,0.00004972413,0.0001469397,0.002514007],"study_design_scores_gemma":[0.001880615,0.001447842,0.007501219,0.0002254141,0.00004020666,0.00003075716,0.000009377818,0.00001595326,0.9882746,0.0002096821,0.0002714487,0.00009289275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950901,0.001488003,0.002834071,0.0001253721,0.0002862311,0.0000770863,0.00005043491,0.00000245203,0.00004622172],"genre_scores_gemma":[0.9988624,0.0002094666,0.0005345907,0.0001193926,0.0002183596,0.000001691714,0.00003222092,0.0000117973,0.00001004524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004967351,"threshold_uncertainty_score":0.4561405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005656445645035795,"score_gpt":0.2450414618646217,"score_spread":0.2393850162195859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}