{"id":"W2083372782","doi":"10.1016/j.clim.2014.08.003","title":"Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens","year":2014,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Medicago (Canada); Montreal General Hospital; Université du Québec; McGill University; Seneca Polytechnic","funders":"","keywords":"Virus-like particle; Vaccination; Virology; Nicotiana benthamiana; Virus; Antigen; Immunology; Hemagglutinin (influenza); T cell; Influenza A virus; CD8; Biology; Immune system; Medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002078698,0.0005568938,0.0001980992,0.0001956016,0.0001210219,0.0002852668,0.000172452,0.0003726532,0.0009296524],"category_scores_gemma":[0.0001447742,0.0001609603,0.0002312783,0.0001210806,0.000190529,0.0001668679,0.0002397285,0.0008603618,0.0004867224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508613,"about_ca_system_score_gemma":0.0001300226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003562241,"about_ca_topic_score_gemma":0.0008870765,"domain_scores_codex":[0.9998094,0.00003201769,0.00001460371,0.00003490528,0.00004638968,0.00006262401],"domain_scores_gemma":[0.9998542,0.0000322036,0.00003829173,0.00002412541,0.00001843222,0.00003267014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003037064,0.0000162362,0.0000500301,0.00000879215,0.000002225014,0.000009495182,0.000007184119,0.00003003872,0.9992982,0.00003063317,0.00001181231,0.0005049208],"study_design_scores_gemma":[0.00001713251,0.0004101542,0.003077683,0.000004956414,0.00002275949,0.00011579,0.0000288914,0.0006502266,0.9942665,0.00005537187,0.001346722,0.000003847857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917977,0.000615678,0.005492353,0.00007562342,0.0000580242,0.00005481124,0.0002313243,0.0001449071,0.001529562],"genre_scores_gemma":[0.9956892,0.000277765,0.00156696,0.00005811592,0.00001232385,0.0000189073,0.0002794389,0.00002129608,0.002075973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009296524,"threshold_uncertainty_score":0.003109992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03261524798941259,"score_gpt":0.3401938554128016,"score_spread":0.307578607423389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}