{"id":"W2083378709","doi":"10.1046/j.1523-1747.2000.00913.x","title":"Pro-opiomelanocortin-Related Peptides, Prohormone Convertases 1 and 2 and the Regulatory Peptide 7B2 are Present in Melanosomes of Human Melanocytes","year":2000,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Melanosome; Autocrine signalling; Melanocyte-stimulating hormone; Biology; Melanocyte; Cell biology; Prohormone; Melanin; Biochemistry; Receptor; Hormone; Melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496746,0.00014384,0.0004085246,0.00009607188,0.0000606519,0.00001214561,0.0001165952,0.0001278054,0.00002803984],"category_scores_gemma":[0.0001248947,0.00009736029,0.00005406221,0.00008477051,0.000974891,0.00001530479,0.00004345475,0.0001608231,7.570922e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000117765,"about_ca_system_score_gemma":0.0000576177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004095012,"about_ca_topic_score_gemma":0.0000412296,"domain_scores_codex":[0.998563,0.0003532885,0.000640174,0.0001584422,0.0001385178,0.0001465981],"domain_scores_gemma":[0.9990411,0.00007589422,0.0005761179,0.0001295183,0.00009766757,0.00007970817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008812674,0.000163576,0.1341544,0.0002285894,0.0005740596,0.0001702127,0.004006355,0.00004756156,0.8521151,0.002483297,0.003960001,0.001215578],"study_design_scores_gemma":[0.004492,0.0003711009,0.1883311,0.0001061851,0.0001075016,0.001428236,0.001003644,0.00006499537,0.7987478,0.004495145,0.0006842605,0.0001680857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930462,0.004967607,0.000002664384,0.001451481,0.00002351955,0.0002735937,0.000007330374,0.000002271877,0.0002253652],"genre_scores_gemma":[0.9985079,0.0007855209,0.0001617492,0.0001717711,0.00003166418,0.00001267534,0.00001643951,0.00001040256,0.0003018764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05417668,"threshold_uncertainty_score":0.3970237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162403875461669,"score_gpt":0.2501527274788357,"score_spread":0.238528688724219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}