{"id":"W2083378709","doi":"10.1046/j.1523-1747.2000.00913.x","title":"Pro-opiomelanocortin-Related Peptides, Prohormone Convertases 1 and 2 and the Regulatory Peptide 7B2 are Present in Melanosomes of Human Melanocytes","year":2000,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Melanosome; Autocrine signalling; Melanocyte-stimulating hormone; Biology; Melanocyte; Cell biology; Prohormone; Melanin; Biochemistry; Receptor; Hormone; Melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001471131,0.0002867764,0.0003143864,0.0009478146,0.0002725171,0.0006622637,0.0001348136,0.000396545,0.0009621901],"category_scores_gemma":[0.0004833146,0.0002481475,0.0002041101,0.0003322978,0.0001962554,0.0003177405,0.0002955159,0.0003308655,0.0003618697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001610506,"about_ca_system_score_gemma":0.0001573384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007244619,"about_ca_topic_score_gemma":0.0006836502,"domain_scores_codex":[0.9998368,0.00002539296,0.00001834126,0.00003650815,0.00004464911,0.0000382461],"domain_scores_gemma":[0.9996351,0.00006104797,0.000088359,0.00003192564,0.00008836643,0.00009516431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003139632,0.00001584045,0.002086699,0.00004340655,0.00001682091,0.0002561909,0.00004769096,0.00001387238,0.9952931,0.00007467363,0.00003882353,0.001798906],"study_design_scores_gemma":[0.00007791114,0.0005673773,0.2718391,0.00003904631,0.0001435467,0.006144994,0.0004048166,0.0005634915,0.710631,0.0006431392,0.008913185,0.00003235022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848232,0.01145361,0.0012648,0.00008885637,0.0000448648,0.00002938887,0.0005703223,0.0000442051,0.001680829],"genre_scores_gemma":[0.9932703,0.001771911,0.001294818,0.00004594234,0.0000505254,0.0000269532,0.001196653,0.00001756801,0.002325193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009621901,"threshold_uncertainty_score":0.003218889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162403875461669,"score_gpt":0.2501527274788357,"score_spread":0.238528688724219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}