{"id":"W2083398319","doi":"10.1182/blood-2012-12-475863","title":"NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Canadian Institutes of Health Research; University of Wisconsin Carbone Cancer Center; Greater Milwaukee Foundation; University of Wisconsin-Madison; American Society of Hematology; V Foundation for Cancer Research","keywords":"Neuroblastoma RAS viral oncogene homolog; Cancer research; Myeloid; Haematopoiesis; Biology; Progenitor cell; Stem cell; MAPK/ERK pathway; Immunology; Signal transduction; Cell biology; Mutation; Genetics; KRAS; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196932,0.000326945,0.0001867826,0.0002295871,0.000126524,0.0002679944,0.0001794698,0.0001891351,0.001288216],"category_scores_gemma":[0.00007458154,0.0001142819,0.0001336941,0.0001212739,0.0003078361,0.0001197907,0.0002119662,0.0003812523,0.0003638268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370978,"about_ca_system_score_gemma":0.0001624164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004857926,"about_ca_topic_score_gemma":0.001439167,"domain_scores_codex":[0.9998498,0.00003280024,0.00001968291,0.0000248737,0.00004272087,0.00003015338],"domain_scores_gemma":[0.9999133,0.00001034256,0.00002873363,0.00001193616,0.000005017755,0.00003065881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001692915,0.00003855914,0.0002759144,0.00001880058,0.00000254955,0.00005161697,0.000006942892,0.00008477935,0.9974543,0.0001494548,0.0000685631,0.001679236],"study_design_scores_gemma":[0.00005597402,0.0004317869,0.00576143,0.000007500456,0.00001310326,0.0006002935,0.00003676065,0.001252449,0.9879821,0.0001256351,0.003728377,0.000004641248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963065,0.0009153034,0.001149262,0.0001626485,0.00001623273,0.00001866923,0.0003269954,0.0001537039,0.0009506572],"genre_scores_gemma":[0.995886,0.0006674696,0.001676326,0.00005157367,0.000007071036,0.00002117526,0.0003207268,0.00001870457,0.001350734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288216,"threshold_uncertainty_score":0.004309475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475485616367521,"score_gpt":0.2378009071536486,"score_spread":0.2230460509899734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}