{"id":"W2083459234","doi":"10.3816/clml.2010.n.059","title":"Phase II Study of Obatoclax Mesylate (GX15-070), a Small-Molecule BCL-2 Family Antagonist, for Patients With Myelofibrosis","year":2010,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"","keywords":"Myelofibrosis; Medicine; Internal medicine; Anemia; Adverse effect; Gastroenterology; Cyclophosphamide; Rash; Surgery; Chemotherapy; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000965681,0.001298136,0.001900264,0.0004065047,0.0003651518,0.0007776057,0.0008073174,0.001002053,0.003133422],"category_scores_gemma":[0.0005169865,0.0005172387,0.0008871771,0.0003190092,0.0009026211,0.0006791047,0.0002765642,0.00229697,0.0009059547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007369386,"about_ca_system_score_gemma":0.001663916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001545829,"about_ca_topic_score_gemma":0.003676163,"domain_scores_codex":[0.9997501,0.0001187989,0.000009354964,0.00003090486,0.00001984409,0.00007105093],"domain_scores_gemma":[0.9995638,0.00007149175,0.00005130172,0.00002902384,0.00002187723,0.0002624801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6813905,0.06698391,0.008327911,0.0008805708,0.001517822,0.0004269959,0.0003817352,0.00495685,0.07646431,0.001167395,0.008685769,0.1488163],"study_design_scores_gemma":[0.6679043,0.3116589,0.009683012,0.00003014381,0.0004061835,0.0003213574,0.00006972646,0.001799075,0.004432136,0.0002564847,0.003409246,0.00002938741],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991971,0.001943538,0.0005124887,0.0006728837,0.0001491271,0.001498431,0.0008308701,0.0001115416,0.002310038],"genre_scores_gemma":[0.9879339,0.001991639,0.001393744,0.001095961,0.0001606627,0.001787052,0.002166367,0.00002885571,0.003441801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003133422,"threshold_uncertainty_score":0.01048231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810113146998339,"score_gpt":0.3297646416348803,"score_spread":0.3016635101648969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}