{"id":"W2083459234","doi":"10.3816/clml.2010.n.059","title":"Phase II Study of Obatoclax Mesylate (GX15-070), a Small-Molecule BCL-2 Family Antagonist, for Patients With Myelofibrosis","year":2010,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"","keywords":"Myelofibrosis; Medicine; Internal medicine; Anemia; Adverse effect; Gastroenterology; Cyclophosphamide; Rash; Surgery; Chemotherapy; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005947117,0.0007238982,0.001797212,0.0001864281,0.0004376525,0.0000596891,0.0003728965,0.0004573674,0.00008201716],"category_scores_gemma":[0.0006563284,0.0005257868,0.0005417772,0.0004388641,0.0004380795,0.0001387624,0.0002228399,0.0003936429,0.00004660479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000357174,"about_ca_system_score_gemma":0.001229465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001520219,"about_ca_topic_score_gemma":0.0001599115,"domain_scores_codex":[0.9951707,0.0001788756,0.001871563,0.001290387,0.00072577,0.0007627259],"domain_scores_gemma":[0.9954002,0.0009875308,0.000751933,0.001269994,0.0008824968,0.0007077731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01477071,0.04927507,0.503628,0.0001999428,0.00177833,0.0001934988,0.000640886,0.000002367996,0.00362709,0.0003618186,0.00201131,0.423511],"study_design_scores_gemma":[0.08139604,0.06599637,0.8374758,0.0002095247,0.001133796,0.00002332281,0.0002122343,0.0002283779,0.007169161,0.00005336029,0.005530482,0.0005715378],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924192,0.00007870701,0.00005832024,0.0001973359,0.0005873116,0.005435687,0.000228145,0.0001347121,0.0008605268],"genre_scores_gemma":[0.9936135,0.00005646936,0.003121843,0.000642597,0.0003548597,0.001386824,0.0002952471,0.0001359933,0.0003926573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4229394,"threshold_uncertainty_score":0.9997194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810113146998339,"score_gpt":0.3297646416348803,"score_spread":0.3016635101648969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}