{"id":"W2083509136","doi":"10.1007/s10549-012-2137-y","title":"111In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic agent for EGFR-positive and trastuzumab (Herceptin)-resistant breast cancer","year":2012,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Aptose Biosciences (Canada); University of Toronto","funders":"","keywords":"Nimotuzumab; Cancer research; Trastuzumab; Chemistry; Monoclonal antibody; Molecular biology; Epidermal growth factor receptor; Receptor; Cancer; Medicine; Breast cancer; Immunology; Antibody; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002673436,0.0002472925,0.0002108652,0.0001044172,0.0001195319,0.000181574,0.0002864756,0.0003806337,0.0005796122],"category_scores_gemma":[0.0001869278,0.0001421387,0.0001114271,0.00009987145,0.0002015442,0.0003221953,0.0002262337,0.0003138384,0.0002016386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000331742,"about_ca_system_score_gemma":0.0001926583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003479447,"about_ca_topic_score_gemma":0.0004274138,"domain_scores_codex":[0.9999127,0.0000240262,0.000004115969,0.00001836323,0.00001761033,0.00002307596],"domain_scores_gemma":[0.9999659,0.000008922954,0.000008836907,0.000004643131,0.000002483865,0.000009222264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005535648,0.00005647219,0.0001591028,0.00006032073,0.000008418679,0.0001674517,0.00002933421,0.000254522,0.9911823,0.0004444988,0.000152615,0.006931485],"study_design_scores_gemma":[0.0001728002,0.0005018159,0.001136728,0.000006254062,0.00002779526,0.0009343958,0.000008240621,0.001659177,0.9909238,0.00006682632,0.004554464,0.000007698484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857213,0.002105993,0.008153579,0.0002190324,0.00004724267,0.00008064826,0.00006673788,0.0001546816,0.003450751],"genre_scores_gemma":[0.98875,0.0006931972,0.007852594,0.00008436233,0.00001287525,0.00003771787,0.0001212166,0.00003969958,0.002408288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005796122,"threshold_uncertainty_score":0.002407014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.090223480004224,"score_gpt":0.4059891096418957,"score_spread":0.3157656296376716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}