{"id":"W2083541383","doi":"10.1074/jbc.m109.012500","title":"Engineering of a Chimeric RB69 DNA Polymerase Sensitive to Drugs Targeting the Cytomegalovirus Enzyme","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; School of Medicine, Emory University; National Institutes of Health; Center for AIDS Research, University of Washington; Emory University; U.S. Department of Veterans Affairs","keywords":"Foscarnet; Human cytomegalovirus; Biology; Polymerase; DNA polymerase; Enzyme; DNA; Nucleotide; Biochemistry; Molecular biology; Virology; Ganciclovir; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001804525,0.0003474945,0.0002794879,0.0001776951,0.0001297118,0.0002810618,0.0002606915,0.0003579985,0.0009166761],"category_scores_gemma":[0.0002075417,0.0001586382,0.0003125029,0.0001802692,0.0002467188,0.000142072,0.0002457614,0.0004816947,0.0004179422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003607489,"about_ca_system_score_gemma":0.0002505267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007883545,"about_ca_topic_score_gemma":0.0007646555,"domain_scores_codex":[0.9998212,0.00003180051,0.0000194149,0.00003631542,0.00005799835,0.00003321734],"domain_scores_gemma":[0.9998626,0.00002118537,0.00005249429,0.00002156201,0.0000130827,0.00002915123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003239046,0.00001294331,0.00004725443,0.00001521429,0.000003599636,0.00003312965,0.000006634473,0.0001015979,0.9990257,0.0001553116,0.000009719779,0.0005564846],"study_design_scores_gemma":[0.00001579023,0.0001770971,0.0006602301,0.000003718791,0.00001076866,0.0002622992,0.000007717443,0.000974222,0.9954106,0.00002754466,0.002445337,0.000004546089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846362,0.0004709043,0.01266652,0.00007301509,0.00003927743,0.00009140327,0.0002881113,0.0001248294,0.00160967],"genre_scores_gemma":[0.9846452,0.0004192305,0.01166762,0.0000262307,0.000007971369,0.00004467579,0.000584279,0.00006201213,0.002542811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009166761,"threshold_uncertainty_score":0.003066659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181137877323675,"score_gpt":0.2824756554177626,"score_spread":0.2643618676853952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}