{"id":"W2083546200","doi":"10.1016/s0006-2952(01)00859-0","title":"Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver☆1☆Portions of this work were presented at the 9th North American ISSX Meeting in Nashville, Tennessee, 1999.1Abbreviations: LPS, lipopolysaccharide; TNF-α, tumor necrosis factor-α; IL, interleukin; IFN, interferon; i.c.v., intracereboventricular(ly); EROD, ethoxyresorufin O-deethylase; PFA, paraformaldehyde; hsp27, heat shock protein 27; PB, phosphate buffer; dLPS, detoxified LPS; HPA, hypothalamic-pituitary-adrenal axis; and iNOS, inducible nitric oxide synthase.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Tumor necrosis factor alpha; Lipopolysaccharide; Internal medicine; Endocrinology; Proinflammatory cytokine; Cytochrome P450; Sickness behavior; Cytokine; Medicine; Central nervous system; Inflammation; Interleukin; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322553,0.0006122024,0.00031753,0.0001865437,0.0002397977,0.0003246156,0.0001545183,0.0002830585,0.003695486],"category_scores_gemma":[0.0002232022,0.0001458943,0.0002578377,0.0001173453,0.0003484858,0.0003857927,0.0002168846,0.0009245661,0.0007847063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004459226,"about_ca_system_score_gemma":0.0003612305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005134903,"about_ca_topic_score_gemma":0.001103422,"domain_scores_codex":[0.9999154,0.0000238594,0.00000569706,0.000016187,0.00001178802,0.0000270347],"domain_scores_gemma":[0.9997899,0.00002263855,0.00004396959,0.00002010359,0.00003513235,0.00008820715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01343818,0.0006887962,0.002073184,0.0003370108,0.00008999386,0.001878258,0.0002151544,0.0001404634,0.9600779,0.001497469,0.001063471,0.0185001],"study_design_scores_gemma":[0.0008441058,0.004376068,0.08171119,0.0001640648,0.0003030657,0.002215268,0.0003992156,0.00207184,0.8957266,0.001987933,0.0101684,0.00003223342],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687418,0.01475701,0.006315558,0.001609051,0.0005101198,0.0001826119,0.001107883,0.0001619455,0.006614099],"genre_scores_gemma":[0.9824789,0.004010932,0.001974728,0.000220598,0.0001615654,0.0001417765,0.0005617421,0.00003313528,0.01041671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003695486,"threshold_uncertainty_score":0.01236266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084283454773909,"score_gpt":0.2497499347721222,"score_spread":0.2389071002243831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}