{"id":"W2083546200","doi":"10.1016/s0006-2952(01)00859-0","title":"Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver☆1☆Portions of this work were presented at the 9th North American ISSX Meeting in Nashville, Tennessee, 1999.1Abbreviations: LPS, lipopolysaccharide; TNF-α, tumor necrosis factor-α; IL, interleukin; IFN, interferon; i.c.v., intracereboventricular(ly); EROD, ethoxyresorufin O-deethylase; PFA, paraformaldehyde; hsp27, heat shock protein 27; PB, phosphate buffer; dLPS, detoxified LPS; HPA, hypothalamic-pituitary-adrenal axis; and iNOS, inducible nitric oxide synthase.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Tumor necrosis factor alpha; Lipopolysaccharide; Internal medicine; Endocrinology; Proinflammatory cytokine; Cytochrome P450; Sickness behavior; Cytokine; Medicine; Central nervous system; Inflammation; Interleukin; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001104859,0.0005716493,0.000967495,0.0004172459,0.0001767698,0.0000326376,0.0009423598,0.0003327407,0.00008339054],"category_scores_gemma":[0.0005792168,0.0003835149,0.000206332,0.001061956,0.0008677025,0.0000570677,0.0008010089,0.0008546417,0.000001827717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008765315,"about_ca_system_score_gemma":0.0001372432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003147931,"about_ca_topic_score_gemma":0.001424526,"domain_scores_codex":[0.9952656,0.001161359,0.001509818,0.0009044569,0.0003857711,0.0007729794],"domain_scores_gemma":[0.9974657,0.0008147117,0.000794851,0.0005865879,0.0001830635,0.0001550966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001599864,0.0008193221,0.05077783,0.00012952,0.0001486926,0.00005261006,0.0004745349,0.00006239491,0.9422137,0.00001179488,0.002889933,0.0008197968],"study_design_scores_gemma":[0.002377196,0.0004445712,0.07704554,0.0001881053,0.0001564036,0.000193482,0.0009053894,0.0006566925,0.9172325,0.00003626711,0.0003717647,0.000392144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819553,0.01463578,0.00002709148,0.001173047,0.00007340836,0.001917609,0.0001844815,0.00001827217,0.00001504762],"genre_scores_gemma":[0.9951255,0.003264864,0.0001347782,0.0007295615,0.00009332,0.0004287876,0.0001451616,0.00004568308,0.00003232611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02626771,"threshold_uncertainty_score":0.9998617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084283454773909,"score_gpt":0.2497499347721222,"score_spread":0.2389071002243831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}