{"id":"W2083547960","doi":"10.1097/01.jto.0000283087.71346.19","title":"PRS-02: Gefitinib (IRESSA) versus docetaxel in patients with locally advanced or metastatic non-small-cell lung cancer pre-treated with platinum-based chemotherapy: a randomized, open-label Phase III study (INTEREST)","year":2007,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Docetaxel; Gefitinib; Lung cancer; Internal medicine; Oncology; Tolerability; Hazard ratio; Population; Clinical endpoint; Randomized controlled trial; Performance status; Chemotherapy; Cancer; Epidermal growth factor receptor; Adverse effect; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001910594,0.002700181,0.004224972,0.0007397354,0.0005981067,0.001561005,0.001502839,0.002120635,0.007252876],"category_scores_gemma":[0.001586195,0.00120235,0.002468807,0.0006968247,0.00205042,0.002199268,0.0004860487,0.005564502,0.001559364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001377365,"about_ca_system_score_gemma":0.001732908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002179744,"about_ca_topic_score_gemma":0.005734812,"domain_scores_codex":[0.9992511,0.000359517,0.00003280098,0.000147763,0.00004395155,0.0001649143],"domain_scores_gemma":[0.9990981,0.0002058493,0.0001736381,0.00007190826,0.00003796486,0.0004125618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9633306,0.01148043,0.0009101978,0.0003211224,0.000826741,0.00004434898,0.00006693848,0.000906936,0.003090344,0.0001189076,0.001044802,0.01785871],"study_design_scores_gemma":[0.8737246,0.1217674,0.002286097,0.00001439544,0.0003974983,0.00006327455,0.00002980487,0.0006081098,0.0005933718,0.0000950953,0.0003971573,0.0000232208],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930003,0.001671721,0.0003331361,0.000672049,0.000329537,0.001367677,0.0009111533,0.0001822813,0.001532204],"genre_scores_gemma":[0.9911073,0.001424216,0.001025171,0.0006835691,0.0003730147,0.001309545,0.00118996,0.00004492947,0.002842297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007252876,"threshold_uncertainty_score":0.02426326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03308441330919291,"score_gpt":0.4527919738624805,"score_spread":0.4197075605532876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}