{"id":"W2083553538","doi":"10.1002/dvdy.21222","title":"<i>Sp1/Sp3</i> compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects","year":2007,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biology; Compound heterozygosity; Embryo; Embryonic stem cell; Embryogenesis; Mutant; Heterozygote advantage; Erythropoiesis; Cell biology; Knockout mouse; Molecular biology; Endocrinology; Internal medicine; Andrology; Genetics; Phenotype; Anemia; Gene; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002469267,0.0002549425,0.0001886135,0.00006214757,0.0002152029,0.00005404187,0.0001310175,0.000211912,0.000009581108],"category_scores_gemma":[0.00003389019,0.0002751051,0.00005794095,0.0001167984,0.0001134496,0.000009281704,0.0002065564,0.0001058246,0.00001057212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001477539,"about_ca_system_score_gemma":0.00006398534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004396301,"about_ca_topic_score_gemma":0.001186006,"domain_scores_codex":[0.9986612,0.000032183,0.0002978266,0.0004267546,0.0001929518,0.0003890342],"domain_scores_gemma":[0.9994647,0.00003117414,0.0001281646,0.000154711,0.00006360292,0.0001576593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004415946,0.0002262856,0.2670303,0.0001101704,0.0001651233,0.00007726235,0.0002703824,0.0001047431,0.7196918,0.00007010507,0.0005009277,0.01131125],"study_design_scores_gemma":[0.002922545,0.0004064172,0.3653952,0.00008437901,0.00006182429,0.000432622,0.001991574,0.001470912,0.6139372,0.0001496814,0.0116662,0.001481423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947469,0.0005242543,0.002760889,0.00004120472,0.0002543059,0.0002265266,0.00009821097,0.00002662182,0.001321107],"genre_scores_gemma":[0.9924199,0.0002534043,0.005797612,0.0003256498,0.00007298476,0.000006298059,0.0006796359,0.00004113852,0.0004033562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1057546,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007008267402691763,"score_gpt":0.2213061777276607,"score_spread":0.214297910324969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}