{"id":"W2083566192","doi":"10.1038/nn815","title":"Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs","year":2002,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":383,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute; AstraZeneca (Canada)","funders":"","keywords":"G protein-coupled receptor; Proenkephalin; Receptor; Enkephalin; Rhodopsin-like receptors; Sensory neuron; Opioid peptide; Neuron; Peptide; Chemistry; Cell biology; Opioid; Biology; Neuroscience; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009775677,0.000353595,0.0003643752,0.0001993803,0.000225589,0.00007850587,0.00107214,0.000156957,0.00003598203],"category_scores_gemma":[0.001308784,0.000300293,0.0001189565,0.001629762,0.0005646869,0.0004622,0.0002663058,0.001065276,0.00009286826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002067312,"about_ca_system_score_gemma":0.0000683035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006201817,"about_ca_topic_score_gemma":3.241304e-7,"domain_scores_codex":[0.9963734,0.000217644,0.0004098483,0.001550114,0.0007265257,0.0007225294],"domain_scores_gemma":[0.9984329,0.0001773248,0.0002848172,0.000773287,0.00009078105,0.0002408487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005569658,0.0001745919,0.00002787777,0.00001906733,4.790538e-7,0.0001381907,0.0000659275,0.0000759918,0.9906784,0.0009975462,0.005194789,0.002571496],"study_design_scores_gemma":[0.0003456706,0.0004630194,0.005222699,0.00001541894,0.000004523585,0.0001505025,0.000005067733,0.0003789102,0.9152238,0.0001803359,0.07774796,0.0002620213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939328,0.0003216181,0.00001612456,0.00109484,0.001526212,0.0005152769,0.0000267291,0.0001788794,0.00238749],"genre_scores_gemma":[0.9886443,0.0005724426,0.0002586254,0.007333335,0.0003178364,0.00000721411,4.254521e-7,0.00004935337,0.002816446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07545448,"threshold_uncertainty_score":0.9999449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07152641889832011,"score_gpt":0.26551231467162,"score_spread":0.1939858957732999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}