{"id":"W2083566192","doi":"10.1038/nn815","title":"Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs","year":2002,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":383,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute; AstraZeneca (Canada)","funders":"","keywords":"G protein-coupled receptor; Proenkephalin; Receptor; Enkephalin; Rhodopsin-like receptors; Sensory neuron; Opioid peptide; Neuron; Peptide; Chemistry; Cell biology; Opioid; Biology; Neuroscience; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457616,0.0003149792,0.000269436,0.0002004484,0.0002314235,0.0004896277,0.0001897739,0.0002570758,0.0009503044],"category_scores_gemma":[0.0001475544,0.0001159271,0.0003392305,0.000139048,0.000261734,0.0004845241,0.0003932555,0.0008288967,0.0003344039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003841503,"about_ca_system_score_gemma":0.000160725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002671115,"about_ca_topic_score_gemma":0.0005344269,"domain_scores_codex":[0.9998683,0.0000147646,0.000007632977,0.00003401266,0.00003666849,0.00003860394],"domain_scores_gemma":[0.9999161,0.00002090285,0.0000148541,0.00001023154,0.00001400489,0.00002390775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001741711,0.00002136863,0.0004230149,0.00002939608,0.000007255143,0.0002005984,0.00002496796,0.00009045819,0.9945441,0.0009345429,0.0001854555,0.003364662],"study_design_scores_gemma":[0.0001046867,0.0007037748,0.03874136,0.00002830495,0.00006933004,0.003678153,0.0003136229,0.003525955,0.92575,0.00182377,0.02522797,0.00003293385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786589,0.003899247,0.009994511,0.0004437083,0.0001616335,0.00004933457,0.0005063833,0.0001103313,0.006175989],"genre_scores_gemma":[0.9723799,0.005141736,0.0123001,0.0006205335,0.0001260649,0.00009464547,0.00142329,0.00004720111,0.00786645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009503044,"threshold_uncertainty_score":0.003179073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07152641889832011,"score_gpt":0.26551231467162,"score_spread":0.1939858957732999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}