{"id":"W2083578913","doi":"10.1128/iai.00609-09","title":"<i>Burkholderia pseudomallei</i>Isocitrate Lyase Is a Persistence Factor in Pulmonary Melioidosis: Implications for the Development of Isocitrate Lyase Inhibitors as Novel Antimicrobials","year":2009,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Melioidosis; Burkholderia pseudomallei; Isocitrate lyase; Microbiology; Biology; Antibiotics; Mycobacterium; Bacteria; Glyoxylate cycle; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948611,0.0002574955,0.0002351389,0.0001041951,0.0001297137,0.0003692739,0.000255148,0.0004229856,0.0008449234],"category_scores_gemma":[0.0001457608,0.00007516071,0.0001008178,0.000101819,0.000386509,0.0003876135,0.0001424276,0.0004787112,0.0003629668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000293285,"about_ca_system_score_gemma":0.0002232667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004207234,"about_ca_topic_score_gemma":0.0003722267,"domain_scores_codex":[0.9999484,0.00001275257,0.000005064193,0.000009383592,0.00001016669,0.00001432439],"domain_scores_gemma":[0.9999226,0.00001678207,0.00002673757,0.000005070384,0.00001027349,0.00001856145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007925971,0.0001187887,0.002354707,0.000270967,0.00001103212,0.0007170317,0.00004168981,0.0002689801,0.9807124,0.001199638,0.0004698634,0.01304221],"study_design_scores_gemma":[0.0002216845,0.001774936,0.01910749,0.00008340757,0.00004584912,0.006534469,0.0001197424,0.002696172,0.9423453,0.001521605,0.02553023,0.00001914753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8895507,0.08776645,0.01023846,0.004687477,0.0001790305,0.000085895,0.0002683898,0.0001236607,0.007100012],"genre_scores_gemma":[0.9869066,0.01018355,0.001257587,0.0002674561,0.00004425098,0.00002006885,0.0001200943,0.000006087833,0.001194272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008449234,"threshold_uncertainty_score":0.002826571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05984274803550417,"score_gpt":0.3086447664483006,"score_spread":0.2488020184127964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}