{"id":"W2083583281","doi":"10.1097/mib.0000000000000245","title":"Benefits and Risks of Combining Anti-tumor Necrosis Factor with Immunomodulator Therapy in Pediatric Inflammatory Bowel Disease","year":2015,"lang":"en","type":"review","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Thiopurine methyltransferase; Inflammatory bowel disease; Methotrexate; Tumor necrosis factor alpha; Internal medicine; Disease; Combination therapy; Lymphoma; Crohn's disease; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009269614,0.0005795206,0.001579347,0.002579521,0.0001898262,0.0007812912,0.0007466023,0.0008463697,0.002358469],"category_scores_gemma":[0.001925103,0.0002258524,0.0009118449,0.002038204,0.0003443619,0.0008396351,0.0004423555,0.0009565559,0.0004341704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005751177,"about_ca_system_score_gemma":0.0009969234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008162888,"about_ca_topic_score_gemma":0.001964892,"domain_scores_codex":[0.9995783,0.0001195924,0.0001152636,0.00005087624,0.000115055,0.00002095517],"domain_scores_gemma":[0.9989409,0.0007268654,0.0001778316,0.00001420745,0.0001098144,0.0000304165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002051465,0.00005364284,0.0005112433,0.08333987,0.0005438135,0.0003337262,0.00008152611,0.0002915939,0.0005319101,0.001368333,0.01398421,0.8987549],"study_design_scores_gemma":[0.0001231202,0.0003052257,0.004866685,0.07897159,0.002524512,0.006859161,0.0001905325,0.0001590881,0.0006869602,0.002430297,0.902836,0.00004683381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000728747,0.9996459,0.00001382515,0.0000709576,0.0000303473,0.000001644137,0.000008045001,9.077527e-7,0.0001554496],"genre_scores_gemma":[0.0006770688,0.9990491,0.0000529182,0.00008981195,0.00005102044,0.00000306226,0.00001117349,4.114032e-7,0.0000652918],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002579521,"threshold_uncertainty_score":0.007889867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03061268451747199,"score_gpt":0.28592761354664,"score_spread":0.255314929029168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}