{"id":"W2083646206","doi":"10.1073/pnas.0806261105","title":"Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Research Resources; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Schizosaccharomyces pombe; Biology; Saccharomyces cerevisiae; Gene; Genetics; Computational biology; Genetic screen; Schizosaccharomyces; Genome; Model organism; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005087867,0.00007504315,0.0001187912,0.00007622415,0.0001166767,0.000006092323,0.0004123068,0.0001050797,0.000006060197],"category_scores_gemma":[0.0003257336,0.0000539954,0.00006968337,0.0003696981,0.0009170747,0.00001368273,0.0001167419,0.0001186438,4.745339e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000101442,"about_ca_system_score_gemma":0.00004476291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001116249,"about_ca_topic_score_gemma":6.839526e-8,"domain_scores_codex":[0.99874,0.00001499593,0.0003342475,0.0002013141,0.0005865949,0.0001228111],"domain_scores_gemma":[0.9992551,0.0000641937,0.0003209948,0.00001239303,0.0003173615,0.00002991782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003034187,0.00002921516,0.09011024,0.00002965287,0.00002261694,9.768702e-9,0.00004041673,0.0008164275,0.9078754,0.0006286992,0.0001920658,0.0002249012],"study_design_scores_gemma":[0.0001024947,0.0001227479,0.287982,0.0000433101,0.000008524788,0.00001051612,0.00003969626,0.00185967,0.7084142,0.001293943,0.00006757071,0.00005537537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978015,0.0001714548,0.00001531408,0.0005866107,0.00001565963,0.0001243775,0.00001382216,0.000002474996,0.001268786],"genre_scores_gemma":[0.9992207,0.0001344861,0.0004219522,0.00002762528,0.00006185307,0.000004520646,0.000001308264,0.000004353171,0.0001231589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1994612,"threshold_uncertainty_score":0.3379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.048920938394365,"score_gpt":0.3070562531466449,"score_spread":0.2581353147522799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}