{"id":"W2083646359","doi":"10.1016/j.ymthe.2004.03.016","title":"A Conditionally Replicating Adenovirus for Nasopharyngeal Carcinoma Gene Therapy","year":2004,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University; University of Toronto; University Health Network","funders":"","keywords":"Nasopharyngeal carcinoma; Biology; Genetic enhancement; Cancer research; Adenoviridae; Cell culture; Epstein–Barr virus; In vivo; Virus; Virology; Ex vivo; Molecular biology; Gene; Radiation therapy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004400321,0.0005710791,0.0003244532,0.00025388,0.0002381876,0.0003813077,0.000487131,0.0004350071,0.001009563],"category_scores_gemma":[0.000211615,0.0002477704,0.0004027539,0.000178606,0.0003412254,0.0003582011,0.0003689848,0.001165147,0.0005149338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003821584,"about_ca_system_score_gemma":0.0005527626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000688717,"about_ca_topic_score_gemma":0.0007565439,"domain_scores_codex":[0.9997533,0.00003987605,0.00002799355,0.00005758948,0.00008907435,0.00003217377],"domain_scores_gemma":[0.9998612,0.00001993611,0.00003432836,0.00003722547,0.00001912028,0.00002812827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004516103,0.00003376546,0.0001047615,0.00008830876,0.000006627592,0.00006570484,0.00002698909,0.000165274,0.9928359,0.0009368233,0.00009180706,0.005598793],"study_design_scores_gemma":[0.00002703655,0.0004068413,0.0008305211,0.00001744466,0.00003758714,0.000745779,0.00001576706,0.001594599,0.9808108,0.0001027979,0.01539264,0.00001831262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7831177,0.01135688,0.1943506,0.0004020011,0.0004112576,0.001010886,0.001896433,0.001056839,0.006397428],"genre_scores_gemma":[0.8942431,0.006257413,0.08965188,0.00008066616,0.00003084229,0.000401905,0.001892577,0.00007913975,0.007362596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009563,"threshold_uncertainty_score":0.003377318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0265819090879531,"score_gpt":0.3088817998288184,"score_spread":0.2822998907408653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}