{"id":"W2083646359","doi":"10.1016/j.ymthe.2004.03.016","title":"A Conditionally Replicating Adenovirus for Nasopharyngeal Carcinoma Gene Therapy","year":2004,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University; University of Toronto; University Health Network","funders":"","keywords":"Nasopharyngeal carcinoma; Biology; Genetic enhancement; Cancer research; Adenoviridae; Cell culture; Epstein–Barr virus; In vivo; Virus; Virology; Ex vivo; Molecular biology; Gene; Radiation therapy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004111226,0.0003275538,0.0002447361,0.00009495563,0.0002254912,0.00006014879,0.0005320558,0.0002115746,0.00005340491],"category_scores_gemma":[0.00004121194,0.0003223653,0.0003032609,0.000175167,0.0001361139,0.00000695804,0.00005831066,0.0001482314,0.00002560389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005848688,"about_ca_system_score_gemma":0.000340198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002243232,"about_ca_topic_score_gemma":0.0000118997,"domain_scores_codex":[0.9978709,0.0001074141,0.0003426011,0.0007651182,0.0003486303,0.0005652872],"domain_scores_gemma":[0.9985604,0.00002048039,0.000127763,0.0008854733,0.000240316,0.0001655617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003163391,0.0002107228,0.0001328109,0.000006233127,0.0002051054,0.00001731763,0.00006641875,0.0005026105,0.9857957,0.0002388343,0.0001855779,0.009475297],"study_design_scores_gemma":[0.006448797,0.004367928,0.0006633441,0.000006020382,0.000005844915,0.00002463195,0.00001542437,0.00001401947,0.9762073,0.001695883,0.01018544,0.0003653203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793116,0.01104997,0.007213859,0.0008197107,0.00008319518,0.00114872,0.00009657199,0.00004781994,0.0002285285],"genre_scores_gemma":[0.9905468,0.0007655162,0.002383389,0.004358038,0.0003743732,0.0006321825,0.0006453766,0.0001299598,0.0001643684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01123517,"threshold_uncertainty_score":0.9999228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0265819090879531,"score_gpt":0.3088817998288184,"score_spread":0.2822998907408653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}