{"id":"W2083663368","doi":"10.1021/ja501581b","title":"Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s","year":2014,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Research Council; Université de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Chemistry; Endocytosis; Cytosol; Biophysics; Endosome; Covalent bond; HeLa; Intracellular; Substrate (aquarium); Biochemistry; Cell; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002820401,0.0001284685,0.0002579991,0.00000944893,0.00004395144,0.0000138517,0.0004547605,0.00007514474,0.0000122586],"category_scores_gemma":[0.00008723164,0.0000888323,0.0005367871,0.0001300801,0.0002502435,0.000004997881,0.0000928984,0.0002160851,0.000001633597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001571118,"about_ca_system_score_gemma":0.00008152811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002006025,"about_ca_topic_score_gemma":8.88626e-7,"domain_scores_codex":[0.9989575,0.0000588925,0.0004487166,0.0001358144,0.0002091292,0.0001900113],"domain_scores_gemma":[0.9986966,0.00002844846,0.0007768275,0.0002442641,0.0001766074,0.00007722159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004899989,0.00005597935,0.002003492,0.00001255351,0.0000722966,4.822471e-7,0.00006060253,0.00001712256,0.9944195,0.000002721656,0.002363272,0.000942939],"study_design_scores_gemma":[0.0002869254,0.0002820938,0.002422289,0.00002482878,0.00004111672,0.00001516981,0.0003638972,0.00008836849,0.9954836,0.00004227502,0.0008469314,0.0001024976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982865,0.0003441196,0.0006417519,0.0001615352,0.00009762673,0.0000328726,0.000004903328,0.000002436497,0.0004282022],"genre_scores_gemma":[0.9974387,0.0001233451,0.001463006,0.0005941089,0.0003028582,6.980295e-7,0.000004502447,0.00001364868,0.00005912086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516341,"threshold_uncertainty_score":0.3622476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245941028527629,"score_gpt":0.244029219994163,"score_spread":0.2315698097088867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}