{"id":"W2083663368","doi":"10.1021/ja501581b","title":"Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s","year":2014,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Research Council; Université de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Chemistry; Endocytosis; Cytosol; Biophysics; Endosome; Covalent bond; HeLa; Intracellular; Substrate (aquarium); Biochemistry; Cell; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109982,0.0002923412,0.0002222092,0.0000809505,0.00008438679,0.0002332866,0.0001327005,0.0001878617,0.0004572331],"category_scores_gemma":[0.000098624,0.00007178595,0.0001265473,0.0001123991,0.0001391326,0.0001695312,0.0001116979,0.0002302967,0.0001734151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151196,"about_ca_system_score_gemma":0.0001275259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264361,"about_ca_topic_score_gemma":0.0003191254,"domain_scores_codex":[0.9999164,0.00001615882,0.000007076312,0.00002596187,0.00001600465,0.00001844229],"domain_scores_gemma":[0.9999311,0.00002418333,0.00001324465,0.000009032955,0.00001083204,0.00001166224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003699307,0.000005826683,0.00005178014,0.00002016341,0.000001795734,0.00002415157,0.00001265163,0.00004034699,0.9991419,0.00007030041,0.00001189455,0.0005821096],"study_design_scores_gemma":[0.00000167323,0.0001021187,0.0003347729,9.027465e-7,0.000003262627,0.00003857663,0.000005638277,0.0002513735,0.9989247,0.000007889977,0.0003281125,0.000001096521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950223,0.0009543803,0.002640798,0.00003225368,0.00001661666,0.00001002604,0.0001124445,0.00003737508,0.001173867],"genre_scores_gemma":[0.995829,0.0005521064,0.002287542,0.00001902335,0.000005758522,0.000007938769,0.0001984068,0.00001160616,0.001088418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004572331,"threshold_uncertainty_score":0.001560748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245941028527629,"score_gpt":0.244029219994163,"score_spread":0.2315698097088867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}