{"id":"W2083733102","doi":"10.1021/ac5029962","title":"In Vitro Selection of a New Lanthanide-Dependent DNAzyme for Ratiometric Sensing Lanthanides","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science","keywords":"Chemistry; Lanthanide; Deoxyribozyme; Selection (genetic algorithm); In vitro; Combinatorial chemistry; Environmental chemistry; Nanotechnology; Biochemistry; Organic chemistry; DNA; Ion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238898,0.0001322714,0.0002347386,0.00007928908,0.00002708417,0.00001282072,0.00008671979,0.0001699328,0.00000441821],"category_scores_gemma":[0.0004642414,0.000123652,0.0001256185,0.000325688,0.00004425682,0.000004656742,0.00003688503,0.00007878925,6.706065e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002304767,"about_ca_system_score_gemma":0.00004461483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003872842,"about_ca_topic_score_gemma":0.00001511831,"domain_scores_codex":[0.9990698,0.0000203759,0.0002715077,0.0003095407,0.0001229908,0.0002057873],"domain_scores_gemma":[0.9995055,0.00004285508,0.00009918457,0.000183872,0.00009532842,0.0000733031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115226,0.00003578668,0.0002541764,0.00003528388,0.0000345195,8.155053e-7,0.000002579662,0.00001091082,0.9964936,0.00001114544,0.000750678,0.002255311],"study_design_scores_gemma":[0.0003264438,0.00006742286,0.00005314196,0.00001389292,0.00004639203,0.00001537068,0.00001548836,0.004776405,0.9921132,0.0002824926,0.002143441,0.0001463271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9179912,0.00007058799,0.08045893,0.0002767826,0.00002741797,0.0001318152,0.00001704595,0.00003363178,0.0009926289],"genre_scores_gemma":[0.9893286,0.00002337973,0.008560636,0.000101068,0.000260947,0.000001576754,0.00007504386,0.00001435369,0.001634438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0718983,"threshold_uncertainty_score":0.5042382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169672603827481,"score_gpt":0.2847794125653892,"score_spread":0.2730826865271144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}