{"id":"W2083791849","doi":"10.1016/s0142-9612(02)00351-4","title":"TNF-α secretion and macrophage mortality induced by cobalt and chromium ions in vitro-Qualitative analysis of apoptosis","year":2002,"lang":"en","type":"article","venue":"Biomaterials","topic":"Orthopaedic implants and arthroplasty","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Orthopaedic Foundation; McGill University","keywords":"Trypan blue; Apoptosis; Macrophage; Toxicity; Tumor necrosis factor alpha; Chromium; Molecular biology; Necrosis; In vitro; Flow cytometry; Secretion; Chemistry; Internal medicine; Biology; Materials science; Endocrinology; Biochemistry; Medicine; Metallurgy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004659027,0.0004029739,0.0003426815,0.0006516376,0.0003454298,0.000369639,0.0002300706,0.0003575351,0.001358668],"category_scores_gemma":[0.0002148701,0.0002655408,0.0004772353,0.0006417696,0.0005377893,0.0003147037,0.0002100218,0.0006719413,0.0003520778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002463249,"about_ca_system_score_gemma":0.0002189695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005321128,"about_ca_topic_score_gemma":0.0008130225,"domain_scores_codex":[0.9994491,0.00009587912,0.00008493269,0.00006894056,0.0001486833,0.0001524867],"domain_scores_gemma":[0.9995841,0.000113781,0.00008300605,0.00004243494,0.0001258124,0.00005078904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006203819,0.00003585716,0.0009850372,0.00007709515,0.00001174431,0.00008952188,0.00008661472,0.00002804689,0.9970123,0.00008404279,0.00001419169,0.0009551875],"study_design_scores_gemma":[0.00002545935,0.0004437569,0.01191155,0.00001377238,0.00004449761,0.0003808839,0.0001809165,0.0003578803,0.9857901,0.0001161637,0.0007253604,0.000009587284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800823,0.005011858,0.01069775,0.0001135706,0.00009755129,0.00007137651,0.0005640946,0.00006661657,0.00329486],"genre_scores_gemma":[0.9882932,0.00147622,0.005053393,0.00008125608,0.00004856731,0.0001154242,0.0005382377,0.00001837044,0.004375391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358668,"threshold_uncertainty_score":0.004545152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04027583319048011,"score_gpt":0.332979124970486,"score_spread":0.2927032917800059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}