{"id":"W2083844605","doi":"10.3899/jrheum.090048","title":"Tacrolimus, a Calcineurin Inhibitor, Overcomes Treatment Unresponsiveness Mediated by P-glycoprotein on Lymphocytes in Refractory Rheumatoid Arthritis","year":2010,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Medicine; Tacrolimus; Rheumatoid arthritis; Calcineurin; Methotrexate; Peripheral blood mononuclear cell; P-glycoprotein; Immunology; Pharmacology; Erythrocyte sedimentation rate; Internal medicine; Gastroenterology; Drug resistance; Multiple drug resistance; Transplantation; In vitro; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002749211,0.0001995997,0.000425118,0.0002265629,0.0002275288,0.0002694804,0.0001583453,0.0001877491,0.0007364654],"category_scores_gemma":[0.0006255998,0.00008533658,0.0001905911,0.0001678913,0.0001451847,0.0001296525,0.0001207814,0.00032214,0.0001705679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229987,"about_ca_system_score_gemma":0.0001560355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000294032,"about_ca_topic_score_gemma":0.0006598686,"domain_scores_codex":[0.9998338,0.00005107274,0.00001536867,0.00001802214,0.00003966072,0.000042005],"domain_scores_gemma":[0.9998605,0.00004604007,0.00003198807,0.00001232532,0.00001294754,0.00003620191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009494494,0.002123002,0.08392788,0.0005452898,0.0002121237,0.002387811,0.0005842001,0.0005627134,0.623975,0.0001233958,0.001641668,0.2744224],"study_design_scores_gemma":[0.00379513,0.03926604,0.7985506,0.0001484476,0.0006935436,0.0221342,0.0005926074,0.002833812,0.1180797,0.0002724857,0.01358982,0.00004366757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966277,0.00271583,0.0001904281,0.00003699184,0.00001247046,0.0000156768,0.00001247128,0.00001177447,0.0003764901],"genre_scores_gemma":[0.9981452,0.0009586383,0.0003589902,0.00007473501,0.00006233752,0.00001924656,0.00007895585,0.000003308832,0.0002985244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007364654,"threshold_uncertainty_score":0.002463758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009371752187979275,"score_gpt":0.2675756993665614,"score_spread":0.2582039471785821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}