{"id":"W2083848338","doi":"10.1016/j.tetasy.2003.10.031","title":"Synthesis of a novel spiro-phosphino-oxazine ligand and its application to Pd-catalyzed asymmetric allylic alkylation","year":2003,"lang":"en","type":"article","venue":"Tetrahedron Asymmetry","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; University of Calgary","keywords":"Tsuji–Trost reaction; Alkylation; Ligand (biochemistry); Chemistry; Malonate; Yield (engineering); Catalysis; Enantiomer; Alcohol; Dimethyl malonate; Allylic alcohol; Medicinal chemistry; Organic chemistry; Combinatorial chemistry; Allylic rearrangement; Enantioselective synthesis; Receptor; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007892345,0.0005035212,0.0008329298,0.001033351,0.0001615724,0.0000587529,0.0004520284,0.0003700237,0.0001518007],"category_scores_gemma":[0.002774285,0.0005067149,0.0002448251,0.003374719,0.00007072206,0.0002447274,0.0001168957,0.0002539409,0.0001245793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001731461,"about_ca_system_score_gemma":0.00008534794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001306209,"about_ca_topic_score_gemma":0.00001591392,"domain_scores_codex":[0.9967231,0.00003939792,0.0009395552,0.0009510114,0.0007716384,0.0005752985],"domain_scores_gemma":[0.9971263,0.0008417613,0.0005114318,0.0009097315,0.0002189287,0.0003917759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001231008,0.001266165,0.01419335,0.000566014,0.0004554517,0.000005219568,0.0001942211,0.00007030128,0.5689598,0.006830253,0.0002775617,0.4070586],"study_design_scores_gemma":[0.0008918173,0.00004090367,0.008838026,0.00009360344,0.0003181797,0.00002598404,0.0002536963,0.001206451,0.9836026,0.00007663219,0.004047263,0.0006047781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9190748,0.003845797,0.009146137,0.0002060458,0.0001044841,0.0004837749,0.0001482489,0.0002004061,0.0667903],"genre_scores_gemma":[0.9960296,0.0002162091,0.002747266,0.00008180403,0.0000982628,0.0001508763,0.00004857457,0.00009152854,0.0005359419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4146429,"threshold_uncertainty_score":0.9997385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133238234213188,"score_gpt":0.2375363688135513,"score_spread":0.2262039864714194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}