{"id":"W2083862691","doi":"10.1371/journal.pone.0044138","title":"A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"National Key Research and Development Program of China; Canadian Institutes of Health Research; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"In vivo; Fulminant hepatitis; Virology; Fulminant; Medicine; Hepatitis; Biology; Chemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002000348,0.0001221208,0.0002066096,0.0000526382,0.00003389345,0.000008656488,0.0001079571,0.0001450176,0.00001609966],"category_scores_gemma":[0.00004257872,0.0001211988,0.00007469753,0.0000577331,0.00002190025,0.000009861558,0.00004915887,0.00006716394,0.00000988134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000350979,"about_ca_system_score_gemma":0.0000321308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002510611,"about_ca_topic_score_gemma":0.00006419273,"domain_scores_codex":[0.9990769,0.00003066382,0.0002917495,0.0002138052,0.0001283299,0.0002585308],"domain_scores_gemma":[0.9994516,0.00001479805,0.0001332809,0.0001655746,0.0001786769,0.00005603499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001701286,0.0006415798,0.001358602,0.0002764077,0.00007613296,9.958214e-7,0.00008957302,0.000004195722,0.9968195,0.00002054328,0.00008775383,0.0004545809],"study_design_scores_gemma":[0.0004123563,0.0004547763,0.001051099,0.000206846,0.00003558099,0.00000265653,0.0001411541,0.0008029722,0.9965757,9.868979e-7,0.000167851,0.0001480109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959266,0.0003337263,0.002773659,0.00001075397,0.0001050715,0.0005926162,0.00005889821,0.000008781274,0.0001898818],"genre_scores_gemma":[0.996132,0.0001456564,0.003074757,0.00002413486,0.0003087964,0.0001151426,0.00002074021,0.00001849566,0.0001602895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007987765,"threshold_uncertainty_score":0.4942344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484315712205197,"score_gpt":0.2182741187217995,"score_spread":0.1698425475012798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}