{"id":"W2083862691","doi":"10.1371/journal.pone.0044138","title":"A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"National Key Research and Development Program of China; Canadian Institutes of Health Research; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"In vivo; Fulminant hepatitis; Virology; Fulminant; Medicine; Hepatitis; Biology; Chemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329898,0.0004611893,0.0002843916,0.0002123428,0.0001500497,0.0002248169,0.0002332873,0.000399845,0.000700652],"category_scores_gemma":[0.00007129707,0.0001154643,0.000180652,0.0001028911,0.0001916094,0.0002344984,0.0001790423,0.0003750791,0.0003143301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000311594,"about_ca_system_score_gemma":0.0002987458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004607519,"about_ca_topic_score_gemma":0.000467241,"domain_scores_codex":[0.9999138,0.00001574549,0.000008266849,0.00002375875,0.00002317845,0.00001530305],"domain_scores_gemma":[0.999953,0.000005206806,0.0000157895,0.00000396034,0.00001116574,0.0000108712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003639326,0.00001552768,0.0000304782,0.00004603729,0.000002295748,0.00002345807,0.000006285741,0.00004491705,0.9982559,0.00004507514,0.00003146602,0.001462236],"study_design_scores_gemma":[0.00002016251,0.0003734906,0.0005038672,0.000003151079,0.00001839173,0.0001373561,0.000005724796,0.0008606918,0.9959028,0.00001399658,0.002155336,0.000004926125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462925,0.004221266,0.04540767,0.0003906946,0.0001346437,0.0002631602,0.0003939136,0.0004676362,0.002428544],"genre_scores_gemma":[0.9764187,0.00184605,0.01657848,0.000171864,0.00002706366,0.0002041183,0.0005368958,0.00004189611,0.004174853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000700652,"threshold_uncertainty_score":0.002343893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484315712205197,"score_gpt":0.2182741187217995,"score_spread":0.1698425475012798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}