{"id":"W2083874631","doi":"10.1371/journal.ppat.1000099","title":"RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Public Health Agency of Canada; Western University","funders":"Robarts Research Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"IRF3; Myxoma virus; Innate immune system; IRF7; Interferon; Biology; Tumor necrosis factor alpha; RIG-I; Interferon type I; Virology; Virus; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009875714,0.0001792451,0.0003148202,0.0001307254,0.0001774439,0.000008045683,0.0001697716,0.0001431319,0.0003371763],"category_scores_gemma":[0.00008230268,0.0001285301,0.00005431364,0.0001301706,0.000394594,0.00006748772,0.00007223455,0.0002713181,0.00008711032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004324901,"about_ca_system_score_gemma":0.00003031122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001574853,"about_ca_topic_score_gemma":0.00002035853,"domain_scores_codex":[0.9988555,0.0002877329,0.000332449,0.0002244334,0.00004401689,0.0002558559],"domain_scores_gemma":[0.9994284,0.0001462519,0.000125956,0.0002220741,0.00006098298,0.00001636912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000470681,0.0002022545,0.008587119,0.00002094443,0.00008168495,0.000009048809,0.001549418,7.451134e-8,0.9866508,0.000006922621,0.00202065,0.0004003823],"study_design_scores_gemma":[0.0006158453,0.0005865291,0.128817,0.00003554301,0.00002235844,0.00005972615,0.0002044304,0.00000131934,0.8683559,0.00000610858,0.001171581,0.0001236578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960832,0.003001206,0.000001680161,0.00009631926,0.0001825546,0.0002166693,0.0002012872,0.00003550875,0.0001815745],"genre_scores_gemma":[0.9981404,0.0005154947,0.000007129413,0.000136982,0.00001496641,0.00001607105,0.0001265027,0.00002062404,0.001021839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1202299,"threshold_uncertainty_score":0.5241306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252848128856447,"score_gpt":0.2459436620385306,"score_spread":0.2234151807499662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}