{"id":"W2083874631","doi":"10.1371/journal.ppat.1000099","title":"RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Public Health Agency of Canada; Western University","funders":"Robarts Research Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"IRF3; Myxoma virus; Innate immune system; IRF7; Interferon; Biology; Tumor necrosis factor alpha; RIG-I; Interferon type I; Virology; Virus; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003724985,0.0003830825,0.0002874786,0.0001803422,0.0001688808,0.0003496632,0.0001416167,0.0002652541,0.001421628],"category_scores_gemma":[0.0002001705,0.0001948835,0.0003712292,0.00008653463,0.0001924773,0.000166789,0.0003679527,0.0004158464,0.0008865872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535313,"about_ca_system_score_gemma":0.0002009904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002902383,"about_ca_topic_score_gemma":0.0003400925,"domain_scores_codex":[0.9997506,0.00006768457,0.00002306685,0.00003464263,0.0000434274,0.0000806543],"domain_scores_gemma":[0.9999026,0.00001937743,0.00002153669,0.00002276125,0.00001383731,0.00001985202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002503046,0.00002204249,0.0005791825,0.00005722743,0.000005367302,0.0002127744,0.00004399126,0.00003284005,0.9975828,0.0001312735,0.00006280578,0.001019462],"study_design_scores_gemma":[0.00008050162,0.0004601125,0.01101849,0.00001823679,0.00002845794,0.001405848,0.0001090802,0.001108006,0.9820243,0.0002078792,0.003532324,0.000006704858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899686,0.00362523,0.003558274,0.0001508339,0.00004943489,0.00005094006,0.0003235893,0.00006937911,0.002203756],"genre_scores_gemma":[0.9960337,0.0008771953,0.001272289,0.00004077703,0.00002303412,0.00004943554,0.0002859436,0.000007366411,0.001410291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421628,"threshold_uncertainty_score":0.004755855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252848128856447,"score_gpt":0.2459436620385306,"score_spread":0.2234151807499662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}