{"id":"W2083880521","doi":"10.1186/1471-2172-10-10","title":"ER stress affects processing of MHC class I-associated peptides","year":2009,"lang":"en","type":"article","venue":"BMC Immunology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"MHC class I; Antigen processing; Major histocompatibility complex; Antigen presentation; Unfolded protein response; Endoplasmic reticulum; Biology; Cell biology; MHC restriction; Immune system; Immunology; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006883006,0.0001523642,0.0002072684,0.00004492813,0.00005940057,0.00001276187,0.0001869669,0.0002037427,0.00001526594],"category_scores_gemma":[0.0001905743,0.0001401444,0.0001045783,0.00008236858,0.0001302184,0.000004437763,0.00005725465,0.00008217465,0.000005148351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001242129,"about_ca_system_score_gemma":0.0001110021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001179103,"about_ca_topic_score_gemma":0.00003178201,"domain_scores_codex":[0.9990864,0.00008770918,0.0001898232,0.0002662132,0.00008614987,0.0002837352],"domain_scores_gemma":[0.9994113,0.000017737,0.0001577924,0.0002765313,0.00008976855,0.00004689552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002753727,0.00038276,0.03272988,0.00005752727,0.00007861917,0.000007962426,0.00005942393,0.0001263814,0.9598357,0.0003216391,0.0006413047,0.005483434],"study_design_scores_gemma":[0.002110584,0.001015984,0.2285905,0.0001217707,0.00006932504,0.000017141,0.000255194,0.0001903009,0.7655784,0.0002857045,0.001391302,0.0003737244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931754,0.003488517,0.0002303949,0.00006267062,0.00008976813,0.0001217316,0.0000237629,0.00002158101,0.002786123],"genre_scores_gemma":[0.998955,0.0001285609,0.0002067617,0.0001010921,0.00005209621,0.000009963303,0.0001322293,0.00001311222,0.0004011447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1958607,"threshold_uncertainty_score":0.5714924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00705389070573471,"score_gpt":0.2405578906902021,"score_spread":0.2335039999844674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}