{"id":"W2083904407","doi":"10.1038/cddis.2014.403","title":"The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model","year":2014,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Unfolded protein response; Endoplasmic reticulum; Cell biology; Apoptosis; Homeostasis; Downregulation and upregulation; ATF4; Biology; Signal transduction; RAC1; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006235771,0.0003351529,0.0001420751,0.0002145665,0.0001560087,0.0002041142,0.0001999723,0.000185577,0.0007854523],"category_scores_gemma":[0.00003601532,0.0001280803,0.0001969015,0.0001066688,0.0002074186,0.0002621088,0.0002282136,0.0004336741,0.0001900605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005039952,"about_ca_system_score_gemma":0.0001995559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007165335,"about_ca_topic_score_gemma":0.00123143,"domain_scores_codex":[0.9999204,0.000008642548,0.000008045453,0.00002251272,0.00001986542,0.00002053123],"domain_scores_gemma":[0.9999509,0.000004051909,0.00001625127,0.000008969815,0.000006184926,0.00001362137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007726812,0.000009969943,0.0001270699,0.00002582189,0.000003086651,0.00006216376,0.000008031429,0.00007155933,0.9988727,0.0001549489,0.00002001796,0.0005672837],"study_design_scores_gemma":[0.00001860276,0.0001472612,0.00446149,0.000005523078,0.00001521717,0.0003054972,0.00002817013,0.001676047,0.9914517,0.0001084345,0.001777057,0.000005134361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954691,0.0008299725,0.002070437,0.00007617464,0.00001533597,0.0000154622,0.0003450801,0.00005806053,0.001120484],"genre_scores_gemma":[0.9939904,0.0005457489,0.002217623,0.00003267551,0.00000342563,0.00002939782,0.0003411585,0.00001108516,0.002828549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007854523,"threshold_uncertainty_score":0.003656805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007262056867586713,"score_gpt":0.2238504919039147,"score_spread":0.216588435036328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}