{"id":"W2083926040","doi":"10.1107/s2053230x14007158","title":"A structural characterization of the isoniazid<i>Mycobacterium tuberculosis</i>drug target, Rv2971, in its unliganded form","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section F Structural Biology Communications","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Australian Research Council; Medical Research Council; Australian Synchrotron; Pfizer","keywords":"Mycobacterium tuberculosis; Isoniazid; Tuberculosis; Computational biology; Drug discovery; Biology; Function (biology); Cloning (programming); Biochemistry; Chemistry; Genetics; Medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940193,0.0002793835,0.0003581687,0.0001182006,0.0002574351,0.0002945398,0.0004369144,0.0004583334,0.0009336121],"category_scores_gemma":[0.0003824658,0.0001239056,0.000325767,0.0003167282,0.0001623414,0.0002796031,0.0001454667,0.0006683698,0.000555822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004191138,"about_ca_system_score_gemma":0.0003342642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001910787,"about_ca_topic_score_gemma":0.001739517,"domain_scores_codex":[0.9998401,0.00002167211,0.00001148992,0.00003189013,0.00006866107,0.00002623316],"domain_scores_gemma":[0.9997994,0.00003483502,0.00003609201,0.00002344827,0.00005642679,0.00004981623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001778844,0.00007485096,0.0007002387,0.00008116477,0.00001039106,0.0003913375,0.0000569296,0.0005403589,0.9940042,0.0002022152,0.0003080657,0.003452389],"study_design_scores_gemma":[0.00009221635,0.0006173982,0.02268396,0.00002707332,0.00005315941,0.002793464,0.0001699557,0.006732286,0.9499041,0.0001627949,0.01673301,0.00003075108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888147,0.002501966,0.003436494,0.0003301988,0.000057715,0.00003289273,0.002196319,0.00009607858,0.002533578],"genre_scores_gemma":[0.9768618,0.001642494,0.006760492,0.0001182508,0.00002129766,0.00001661877,0.01231247,0.00005513439,0.002211557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001910787,"threshold_uncertainty_score":0.003799379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009381901573279127,"score_gpt":0.252602759413139,"score_spread":0.2432208578398599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}