{"id":"W2083949023","doi":"10.1006/excr.2000.5010","title":"A Conformational Change in PBX1A Is Necessary for Its Nuclear Localization","year":2000,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Nuclear localization sequence; Biology; Fusion protein; DNA; Nuclear transport; Nuclear protein; NLS; Mutation; Homeobox; Cell biology; Conformational change; Molecular biology; Cell nucleus; Gene; Genetics; Biophysics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000307612,0.0004367659,0.0003970401,0.0001668969,0.0007483306,0.0005675374,0.0004615207,0.0006786845,0.005838231],"category_scores_gemma":[0.0005658118,0.0003096124,0.0005806366,0.0001591133,0.0008181733,0.0006561627,0.0005841673,0.001520592,0.002664997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004819682,"about_ca_system_score_gemma":0.0003326449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000453496,"about_ca_topic_score_gemma":0.0003690963,"domain_scores_codex":[0.9998104,0.00003612725,0.0000200986,0.00006275644,0.00003178922,0.00003874802],"domain_scores_gemma":[0.9993157,0.0001916785,0.0001254164,0.0001442296,0.00004703671,0.0001758707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005409434,0.00006625675,0.0004288723,0.0000527002,0.00001575684,0.0003495618,0.00002632864,0.0001487461,0.9960025,0.0006814403,0.0001435023,0.001543367],"study_design_scores_gemma":[0.00009886831,0.0001881078,0.004989084,0.00001353285,0.00001719001,0.001311861,0.00004655631,0.0007792408,0.9892511,0.0004078832,0.00287515,0.0000214024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885577,0.001445069,0.005929942,0.0008309993,0.000231022,0.00004063211,0.0003009864,0.0002907422,0.002372965],"genre_scores_gemma":[0.9962213,0.0002135805,0.001426948,0.0001494481,0.00003436605,0.00003800389,0.0005435322,0.00006476769,0.001308177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005838231,"threshold_uncertainty_score":0.01953089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06251283265623811,"score_gpt":0.381931337610582,"score_spread":0.3194185049543439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}