{"id":"W2083949023","doi":"10.1006/excr.2000.5010","title":"A Conformational Change in PBX1A Is Necessary for Its Nuclear Localization","year":2000,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Nuclear localization sequence; Biology; Fusion protein; DNA; Nuclear transport; Nuclear protein; NLS; Mutation; Homeobox; Cell biology; Conformational change; Molecular biology; Cell nucleus; Gene; Genetics; Biophysics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002557729,0.00007662648,0.0000623132,0.00006550522,0.0001372097,0.000017449,0.000111557,0.0001305572,0.000947418],"category_scores_gemma":[0.000005305328,0.0000784248,0.0000299994,0.0001087259,0.00006301015,0.00001379594,0.00005264144,0.00006027632,0.0001532915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003743079,"about_ca_system_score_gemma":0.00003617755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001739465,"about_ca_topic_score_gemma":0.000006621007,"domain_scores_codex":[0.999204,0.00005784996,0.0001377591,0.0002131059,0.0001505379,0.0002367793],"domain_scores_gemma":[0.9997813,0.000009117768,0.00001638735,0.00009520358,0.00005056844,0.00004745073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008352249,0.0003233714,0.001669041,0.00004164208,0.00001484915,0.000001634693,0.002020043,0.00003859892,0.9690604,0.000263409,0.01445306,0.01127871],"study_design_scores_gemma":[0.0007579662,0.0002876273,0.001451658,0.000008098352,5.527027e-7,0.000002737055,0.00036083,0.001658591,0.8688941,0.00002851867,0.1264394,0.0001099727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986425,0.001376646,0.00002363377,0.0002085741,0.00004487077,0.0005532919,0.000019614,0.000006359552,0.01134204],"genre_scores_gemma":[0.9952862,0.000152926,0.0001592116,0.0005125684,0.00009988313,0.000149751,0.0005154925,0.00001210867,0.003111845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1119863,"threshold_uncertainty_score":0.9999658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06251283265623811,"score_gpt":0.381931337610582,"score_spread":0.3194185049543439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}