{"id":"W2083984414","doi":"10.1002/stem.289","title":"A Unique Interplay Between Rap1 and E-Cadherin in the Endocytic Pathway Regulates Self-Renewal of Human Embryonic Stem Cells    ","year":2009,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Blood Services; Fondazione Telethon; Government of Ontario; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Ontario Genomics Institute","keywords":"Biology; Embryonic stem cell; Endocytic cycle; Cell biology; Cadherin; Stem cell; Rap1; Endocytosis; Genetics; Signal transduction; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007329059,0.0002651823,0.0003481888,0.0001162506,0.00007694968,0.00004815907,0.0005259279,0.0002266231,0.000008890965],"category_scores_gemma":[0.000002312918,0.0002078129,0.0001157421,0.0001879938,0.0001090006,0.000008151091,0.0001722959,0.000237226,0.00001093513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004205569,"about_ca_system_score_gemma":0.0001009968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002999476,"about_ca_topic_score_gemma":0.00003640432,"domain_scores_codex":[0.9978678,0.0004305053,0.0004467594,0.0004922395,0.0002880788,0.0004746758],"domain_scores_gemma":[0.9990416,0.00008093889,0.0001531313,0.0005574856,0.00006111396,0.0001056958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003703237,0.00009025598,0.001096893,0.00009865739,0.00004836844,0.0000208969,0.0005572942,0.00001000281,0.9960709,0.00004037506,0.0001892698,0.001740044],"study_design_scores_gemma":[0.0008035127,0.0008575768,0.001170364,0.00006771232,0.00002049998,0.00001258352,0.0003775484,0.00003237844,0.994949,0.00008503543,0.001402369,0.0002213534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971359,0.0009065649,0.00002440582,0.00008713894,0.00004943522,0.0005781265,0.00003643237,0.0000167662,0.001165236],"genre_scores_gemma":[0.9976904,0.0002316215,0.00005361427,0.00005708808,0.00008392327,0.00001654037,0.00002086159,0.00002482766,0.001821104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518691,"threshold_uncertainty_score":0.8474365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359578786928194,"score_gpt":0.2702522356491788,"score_spread":0.2566564477798968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}