{"id":"W2083984414","doi":"10.1002/stem.289","title":"A Unique Interplay Between Rap1 and E-Cadherin in the Endocytic Pathway Regulates Self-Renewal of Human Embryonic Stem Cells    ","year":2009,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Blood Services; Fondazione Telethon; Government of Ontario; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Ontario Genomics Institute","keywords":"Biology; Embryonic stem cell; Endocytic cycle; Cell biology; Cadherin; Stem cell; Rap1; Endocytosis; Genetics; Signal transduction; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001663933,0.000277487,0.0002181526,0.0001753178,0.0001714754,0.0004773806,0.0001561164,0.0002806061,0.0003451788],"category_scores_gemma":[0.0001536167,0.0001584178,0.000146357,0.0001117389,0.0002411709,0.0002987301,0.0002661658,0.0003326347,0.0002382319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001998901,"about_ca_system_score_gemma":0.0001644981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122413,"about_ca_topic_score_gemma":0.0002199087,"domain_scores_codex":[0.9998765,0.00002479782,0.000009959548,0.00003042775,0.00003367331,0.00002447353],"domain_scores_gemma":[0.9999245,0.00001714523,0.0000235812,0.00001026544,0.00001008318,0.00001433812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003353694,0.000006986731,0.0004268542,0.00005022661,0.000006514691,0.0001333577,0.00001798965,0.0001592729,0.9934151,0.0003900423,0.00002817498,0.005332012],"study_design_scores_gemma":[0.00000862352,0.0001194905,0.01026245,0.00000991407,0.00004379536,0.001773661,0.00004713097,0.002072589,0.9805567,0.0002459373,0.00485084,0.000008752583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808071,0.01182771,0.005367986,0.0002093747,0.0000131419,0.0000104317,0.00007400766,0.00008185951,0.001608373],"genre_scores_gemma":[0.9940996,0.003076373,0.001842333,0.00003958895,0.00001078175,0.00001105363,0.00007770206,0.000009123914,0.0008334045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004773806,"threshold_uncertainty_score":0.001450241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359578786928194,"score_gpt":0.2702522356491788,"score_spread":0.2566564477798968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}