{"id":"W2083992079","doi":"10.1038/sj.cdd.4401360","title":"Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors","year":2004,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"National Cancer Institute","keywords":"Active site; Protein subunit; Proteolysis; Caspase; Cell biology; Biochemistry; Enzyme activator; Chemistry; Enzyme; Heterotetramer; Mutant; Biology; Apoptosis; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004720466,0.00009286307,0.0001077842,0.00002465462,0.00008007082,0.000007667589,0.0000505256,0.00009408467,0.000004353464],"category_scores_gemma":[0.00002607327,0.00007216769,0.00006620175,0.0000580745,0.00003219643,0.00000963626,0.000029737,0.00002172071,1.630301e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001841452,"about_ca_system_score_gemma":0.00003666899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002384528,"about_ca_topic_score_gemma":0.00001617979,"domain_scores_codex":[0.9994529,0.00002376616,0.0001581176,0.0001808322,0.00009832295,0.00008600182],"domain_scores_gemma":[0.9994979,0.00001189813,0.0002007285,0.0001533126,0.0001069755,0.00002921858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006943264,0.00009691553,0.0002678916,0.00009738361,0.00001340063,1.215563e-8,0.0001052392,0.000072458,0.9969268,0.0002686287,0.00003937176,0.002042437],"study_design_scores_gemma":[0.0007159631,0.0001307343,0.01038718,0.00001803056,0.00005596055,6.390831e-7,0.00003521357,0.001091208,0.9870418,0.0003514535,0.00009546783,0.00007638139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736506,0.0001776522,0.0254407,0.00006690482,0.00007985729,0.0004061027,0.0001137226,0.000003257034,0.00006116046],"genre_scores_gemma":[0.9991946,0.00008390717,0.0001122986,0.00001343794,0.00002475448,0.00001444893,0.0003888135,0.000009582104,0.0001581798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02554393,"threshold_uncertainty_score":0.2942913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01686674872822828,"score_gpt":0.2312108616362584,"score_spread":0.2143441129080301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}