{"id":"W2083998120","doi":"10.1016/j.jbior.2014.09.003","title":"Protein arginine methyltransferases (PRMTs): Role in chromatin organization","year":2014,"lang":"en","type":"review","venue":"Advances in Biological Regulation","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canada Research Chairs; CancerCare Manitoba Foundation; Research Manitoba","keywords":"Methyltransferase; Protein arginine methyltransferase 5; Chromatin; Histone; Effector; Methylation; Biology; Histone methyltransferase; Arginine; Histone-modifying enzymes; Biochemistry; Genetics; Cell biology; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004434942,0.0006835785,0.0009380861,0.0008857002,0.0002047701,0.000774901,0.000820749,0.0007976552,0.001658393],"category_scores_gemma":[0.0003995959,0.0001965826,0.0002573063,0.001548766,0.000569238,0.0008469232,0.0006427743,0.001380752,0.001241058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236556,"about_ca_system_score_gemma":0.0007254518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005977195,"about_ca_topic_score_gemma":0.001162388,"domain_scores_codex":[0.9998606,0.00001599784,0.00001438717,0.00003082848,0.00005874687,0.00001929423],"domain_scores_gemma":[0.9998604,0.00004636334,0.00003268972,0.000005362807,0.00003324342,0.00002189905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001063014,0.00003399543,0.0003069733,0.006081104,0.0000695113,0.0002241589,0.00003846156,0.0004610879,0.01101176,0.0039901,0.0194526,0.9582239],"study_design_scores_gemma":[0.00001824305,0.00005652552,0.0008897832,0.0005433394,0.00008941039,0.001070826,0.00004238312,0.0001367432,0.003281842,0.002172999,0.9916822,0.00001561549],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002872158,0.9978421,0.0004869632,0.0003188034,0.0001840976,0.000003184302,0.00002447066,0.00001381874,0.0008393309],"genre_scores_gemma":[0.002346827,0.9958485,0.0004486177,0.0002049979,0.0002023857,0.00000475555,0.00006001002,0.000001885818,0.0008818975],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001658393,"threshold_uncertainty_score":0.005547822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253025298857068,"score_gpt":0.3024075415570268,"score_spread":0.2898772885684561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}