{"id":"W2083998120","doi":"10.1016/j.jbior.2014.09.003","title":"Protein arginine methyltransferases (PRMTs): Role in chromatin organization","year":2014,"lang":"en","type":"review","venue":"Advances in Biological Regulation","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canada Research Chairs; CancerCare Manitoba Foundation; Research Manitoba","keywords":"Methyltransferase; Protein arginine methyltransferase 5; Chromatin; Histone; Effector; Methylation; Biology; Histone methyltransferase; Arginine; Histone-modifying enzymes; Biochemistry; Genetics; Cell biology; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000408718,0.0004228243,0.0009162117,0.0002266175,0.00004454339,0.00002056321,0.0002472691,0.0008996572,0.00006326605],"category_scores_gemma":[0.0004873186,0.0003458261,0.0001520057,0.0008229144,0.0001039334,0.00002062997,0.00007103912,0.0002441753,0.00001998795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000163942,"about_ca_system_score_gemma":0.0001020774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009726161,"about_ca_topic_score_gemma":0.0001168669,"domain_scores_codex":[0.9973713,0.0004738429,0.0008903758,0.0007806108,0.0001662851,0.0003175891],"domain_scores_gemma":[0.9990444,0.0000702308,0.0003690321,0.0003852842,0.00007796693,0.00005311097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003506935,0.0000703089,0.0002298278,0.0009207056,0.00001944666,0.000001040471,0.00001031432,0.001807089,0.008672947,0.0003747608,0.00001201134,0.9878465],"study_design_scores_gemma":[0.0005666743,0.0003221634,0.001031075,0.00309557,0.0000427233,0.00001355127,0.00000748146,0.000174397,0.003613207,0.0009168662,0.9895955,0.0006208112],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008186491,0.9867439,0.003206579,0.00002151575,0.0001413384,0.001414291,0.00001955839,0.00003768187,0.0002286663],"genre_scores_gemma":[0.0372448,0.9579003,0.0009613015,0.000014177,0.00035082,0.0002303531,0.00314934,0.00005236579,0.00009649795],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9895835,"threshold_uncertainty_score":0.9998994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253025298857068,"score_gpt":0.3024075415570268,"score_spread":0.2898772885684561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}