{"id":"W2084004132","doi":"10.1038/nmeth.f.292","title":"The mysteries of induced pluripotency: where will they lead?","year":2009,"lang":"en","type":"article","venue":"Nature Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Induced pluripotent stem cell; Computational biology; Somatic cell; Biology; Transcription factor; Cell biology; Transcription (linguistics); Set (abstract data type); Genetics; Computer science; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02065025,0.0008165217,0.002762816,0.0009038575,0.002257865,0.008126719,0.002613494,0.006324715,0.00639139],"category_scores_gemma":[0.02212037,0.0007230958,0.001179926,0.0009908987,0.01466058,0.02882477,0.005368799,0.0152457,0.002697223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002347779,"about_ca_system_score_gemma":0.003680857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007678088,"about_ca_topic_score_gemma":0.00108562,"domain_scores_codex":[0.9957255,0.001798866,0.0002976908,0.000305539,0.001356577,0.0005158132],"domain_scores_gemma":[0.9880818,0.007370575,0.0008667756,0.001256884,0.001434658,0.0009893121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007337022,0.0002526395,0.003385,0.00121507,0.0001418267,0.0007232901,0.001697175,0.001094561,0.008894259,0.7215187,0.04239843,0.2179455],"study_design_scores_gemma":[0.0001091378,0.0002568476,0.001075671,0.0005483555,0.00006456091,0.0007233683,0.002442568,0.001507714,0.00631205,0.8101546,0.1766658,0.0001394589],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.03147225,0.4999134,0.07020064,0.3592176,0.01242036,0.0001503818,0.0005066044,0.0005586781,0.02556014],"genre_scores_gemma":[0.4118458,0.4179152,0.05498415,0.08004088,0.01629066,0.0008286193,0.0007819579,0.0004083667,0.01690441],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.02065025,"threshold_uncertainty_score":0.1092103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579945443600145,"score_gpt":0.3610428601186978,"score_spread":0.3452434056826963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}