{"id":"W2084004132","doi":"10.1038/nmeth.f.292","title":"The mysteries of induced pluripotency: where will they lead?","year":2009,"lang":"en","type":"article","venue":"Nature Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Induced pluripotent stem cell; Computational biology; Somatic cell; Biology; Transcription factor; Cell biology; Transcription (linguistics); Set (abstract data type); Genetics; Computer science; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001295277,0.0001662023,0.0001952593,0.00004169956,0.0001377816,0.00003134113,0.000543762,0.0005073976,0.00000808232],"category_scores_gemma":[0.0005488394,0.0001069334,0.000133061,0.0001343307,0.00009077335,0.000005889731,0.0001254572,0.0005133805,0.000003024114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001385613,"about_ca_system_score_gemma":0.00009560947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007429512,"about_ca_topic_score_gemma":0.00003443196,"domain_scores_codex":[0.9982641,0.0005839881,0.0002368949,0.0003114754,0.0002770448,0.0003265001],"domain_scores_gemma":[0.9988682,0.0001034262,0.0001080521,0.0006597373,0.0001967901,0.0000638174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001129589,0.00002510647,0.00007976082,0.00001670761,0.00003789556,0.000002160403,0.00005848131,0.000002841081,0.9357882,0.0005918609,0.001071867,0.06221212],"study_design_scores_gemma":[0.0002571619,0.0003622265,0.001793863,0.0000200624,0.00001193183,0.00001389281,0.0000733691,0.00002628908,0.8129072,0.001708478,0.182685,0.0001405619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8161314,0.08606146,0.02491527,0.01391027,0.00208966,0.001609711,0.00005410486,0.00009881528,0.05512934],"genre_scores_gemma":[0.9664999,0.0009923563,0.02872573,0.0002697263,0.0002383694,0.000009840808,0.00001481925,0.00002068415,0.003228624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1816132,"threshold_uncertainty_score":0.4360617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579945443600145,"score_gpt":0.3610428601186978,"score_spread":0.3452434056826963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}