{"id":"W2084006614","doi":"10.1160/th11-10-0740","title":"Simultaneous measurement of adenosine triphosphate release and aggregation potentiates human platelet aggregation responses for some subjects, including persons with Quebec platelet disorder","year":2012,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Platelet; Platelet aggregation; Firefly protocol; Adenosine diphosphate; Luciferase; Adenosine triphosphate; Chemistry; Granule (geology); Epinephrine; Long-term potentiation; Whole blood; Adenosine monophosphate; Ristocetin; Adenosine; Pharmacology; Medicine; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040779,0.0002090792,0.0002747414,0.00006855559,0.0003238584,0.00004490308,0.0000606531,0.0001127817,0.00001663328],"category_scores_gemma":[0.0001080711,0.0001764237,0.00005828259,0.00007233927,0.00009042556,0.00003508136,0.00004796421,0.00005675177,2.833386e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002916506,"about_ca_system_score_gemma":0.00003815746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005373944,"about_ca_topic_score_gemma":0.0003341476,"domain_scores_codex":[0.9989076,0.00006308363,0.000254038,0.0002889103,0.0002042629,0.0002821327],"domain_scores_gemma":[0.999351,0.00005182994,0.0002026539,0.0001508843,0.0001368172,0.000106851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001082241,0.0002025683,0.004514582,0.0002203539,0.0003676377,0.000001581972,0.000943299,0.0001227638,0.927183,0.0004109213,0.0001670125,0.06478404],"study_design_scores_gemma":[0.001834856,0.000590752,0.001960223,0.000153134,0.000139156,0.00001016401,0.0006752624,0.0002311027,0.9928924,0.00007330358,0.001155219,0.0002844072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894525,0.00754901,0.002275261,0.0001441369,0.00005002995,0.0004320348,0.00007745473,0.00001370414,0.000005897904],"genre_scores_gemma":[0.9968282,0.001347627,0.001403156,0.00005580852,0.00009637986,0.00003520323,0.0001405558,0.00003379318,0.00005925921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06570941,"threshold_uncertainty_score":0.7194349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04055096495363581,"score_gpt":0.2860815944750312,"score_spread":0.2455306295213954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}