{"id":"W2084015000","doi":"10.1089/104303401750476249","title":"Dystrophin Expression in Muscle Following Gene Transfer with a Fully Deleted (\"Gutted\") Adenovirus Is Markedly Improved by Trans-Acting Adenoviral Gene Products","year":2001,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Dystrophin; Duchenne muscular dystrophy; Biology; mdx mouse; Myogenesis; Genetic enhancement; Molecular biology; Muscular dystrophy; Viral vector; Transgene; Adenoviridae; Gene; Myocyte; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006110494,0.0006380323,0.0005052319,0.0002244201,0.0003607582,0.000104766,0.0006783333,0.0003507919,0.0002103272],"category_scores_gemma":[0.00001231722,0.0005791911,0.0002285663,0.0005405864,0.0001345854,0.00003644708,0.00005364208,0.0004450522,0.000008328916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009791575,"about_ca_system_score_gemma":0.0002199324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001225356,"about_ca_topic_score_gemma":0.0002231174,"domain_scores_codex":[0.9960275,0.0003587602,0.0006061526,0.001320013,0.0005660469,0.00112156],"domain_scores_gemma":[0.9984879,0.00001505828,0.0001087484,0.00101345,0.0001459688,0.000228868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008095376,0.0003673554,0.0004603401,0.00001588819,0.0002051651,0.0001092878,0.0006978592,0.0000509651,0.9738884,2.079188e-7,0.0002530373,0.0158561],"study_design_scores_gemma":[0.007227217,0.004913569,0.00109376,0.0000363228,0.00002216439,0.00004117874,0.00009530786,0.00005877489,0.9813483,0.00000929501,0.004424366,0.0007297671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898879,0.006402266,0.001829452,0.0003570271,0.00008010371,0.001227544,0.00005931619,0.00007330214,0.00008309883],"genre_scores_gemma":[0.9948155,0.001488193,0.001011554,0.0006890364,0.0004098776,0.0002288662,0.0003818735,0.0002236388,0.0007514581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01512633,"threshold_uncertainty_score":0.999666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02096628237288385,"score_gpt":0.2745565965561002,"score_spread":0.2535903141832163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}