{"id":"W2084030449","doi":"10.1371/journal.pone.0023202","title":"HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; Fogarty International Center; National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; U.S. Public Health Service; National Institutes of Health; York University; U.S. Department of Veterans Affairs","keywords":"Lymphocyte function-associated antigen 1; Infectivity; Biology; Cell adhesion; Cell biology; Virus; Virology; Cell; Cell adhesion molecule; Intercellular Adhesion Molecule-1; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009423104,0.0002137485,0.0001363229,0.0001867605,0.0001358216,0.0003312666,0.0001047996,0.0003380627,0.002272754],"category_scores_gemma":[0.0001340592,0.00009992784,0.0001873948,0.0001052057,0.00008822246,0.0001472139,0.0001983668,0.0003109311,0.0002138537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805311,"about_ca_system_score_gemma":0.0001077557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001961912,"about_ca_topic_score_gemma":0.0002163084,"domain_scores_codex":[0.9998835,0.00003209707,0.000005708876,0.00001277568,0.0000204937,0.00004540659],"domain_scores_gemma":[0.9999563,0.00001188,0.00001087869,0.000005927491,0.000004874942,0.00001024634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001066944,0.0000385729,0.000558159,0.00003072454,0.000005505975,0.00005484104,0.0000165225,0.00003076476,0.995741,0.00005898005,0.00002866495,0.003329647],"study_design_scores_gemma":[0.00006734936,0.001857515,0.03325804,0.00002048342,0.00004468906,0.0007948772,0.00007479657,0.0009870892,0.9595649,0.0002149804,0.00310757,0.000007656897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977065,0.001159578,0.0003796485,0.00004233104,0.000008202083,0.00001191524,0.00004208438,0.00002131687,0.0006283775],"genre_scores_gemma":[0.9981831,0.0005742697,0.0002823373,0.00002882986,0.00001344942,0.00001144195,0.00007609666,0.000002598828,0.0008279628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002272754,"threshold_uncertainty_score":0.007603109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04934838514246934,"score_gpt":0.228074706920672,"score_spread":0.1787263217782027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}