{"id":"W2084035806","doi":"10.1074/jbc.m710433200","title":"A Proton-mediated Conformational Shift Identifies a Mobile Pore-lining Cysteine Residue (Cys-561) in Human Concentrative Nucleoside Transporter 3","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nucleoside; Cysteine; Biochemistry; Biology; Pyrimidine; Residue (chemistry); Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019413,0.0002142274,0.0002479299,0.00005892921,0.0001371348,0.000170531,0.0001691847,0.0003641843,0.001337923],"category_scores_gemma":[0.000149017,0.00009033706,0.0002732106,0.00006278092,0.0002147726,0.0001360192,0.0001290657,0.0003216272,0.0003096761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002855242,"about_ca_system_score_gemma":0.0001459356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007447223,"about_ca_topic_score_gemma":0.0006085971,"domain_scores_codex":[0.9999474,0.000008258822,0.000003864978,0.00001806869,0.00001077663,0.00001166606],"domain_scores_gemma":[0.9999288,0.00001840869,0.00002202975,0.000006505384,0.000007936696,0.00001619535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002105957,0.00001232701,0.0004995865,0.00003000395,0.000007827415,0.0002699241,0.00002984473,0.0001299703,0.9976902,0.0001073219,0.00002863657,0.0009837465],"study_design_scores_gemma":[0.00003533304,0.0003224796,0.008194618,0.000006697896,0.00002672903,0.001387648,0.00003383161,0.001211747,0.9875585,0.00006221631,0.001150405,0.000009842238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978829,0.0003322221,0.00117489,0.00005098096,0.00001510522,0.00001178966,0.0001058515,0.00001792637,0.0004084125],"genre_scores_gemma":[0.998091,0.000180342,0.001019587,0.00004372195,0.00000609676,0.000005964794,0.0001729788,0.000007356285,0.000473007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337923,"threshold_uncertainty_score":0.004475772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01953568148117062,"score_gpt":0.2632963707125541,"score_spread":0.2437606892313834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}