{"id":"W2084058063","doi":"10.1016/j.bcp.2009.09.025","title":"Predicting gemcitabine transport and toxicity in human pancreatic cancer cell lines with the positron emission tomography tracer 3′-deoxy-3′-fluorothymidine","year":2009,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Alberta Cancer Foundation","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Gemcitabine; Pancreatic cancer; Toxicity; Deoxycytidine; Positron emission tomography; Chemistry; Oncology; Nucleoside transporter; Internal medicine; Cancer research; Medicine; Pharmacology; Nuclear medicine; Cancer; Biochemistry; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002943343,0.0002219305,0.0005266035,0.00008492693,0.0001256925,0.000005782875,0.0001222996,0.0002078093,0.0003256011],"category_scores_gemma":[0.00001514829,0.0001362335,0.00006242552,0.000265564,0.0002934866,0.00005413524,0.00002279739,0.0004744623,8.825656e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001049413,"about_ca_system_score_gemma":0.0001068093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002648566,"about_ca_topic_score_gemma":0.00002076149,"domain_scores_codex":[0.9985279,0.00009359717,0.0003167789,0.0003830085,0.0002192815,0.000459467],"domain_scores_gemma":[0.9993148,0.0001476399,0.00008036681,0.0001471534,0.00007423628,0.0002358307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009974639,0.0004042427,0.2586251,0.00008242001,0.00005918209,0.00004730737,0.000228871,0.000001234016,0.736006,0.000003554178,0.003390906,0.0001537743],"study_design_scores_gemma":[0.005278264,0.001402919,0.4182772,0.0001307674,0.0006617938,0.00005962438,0.0001022774,0.0005038457,0.5731133,0.00003693828,0.0002403054,0.0001928125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863705,0.005494418,0.00002213398,0.005915827,0.00003313379,0.000831145,0.000009188137,0.00005036797,0.001273299],"genre_scores_gemma":[0.9969655,0.0006556436,0.0002235092,0.001295784,0.000305882,0.0001120803,0.00002271459,0.00001721755,0.0004016976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1628927,"threshold_uncertainty_score":0.5555441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538200891288636,"score_gpt":0.3337432054254031,"score_spread":0.3183611965125168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}