{"id":"W2084075389","doi":"10.1158/1538-7445.am10-554","title":"Abstract 554: Crosstalk between TNF-α and IGF signalling increases IL-6 production and protects tumor cells from TNF-α-induced apoptosis in the liver","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Tumor necrosis factor alpha; Cancer research; Cytokine; Metastasis; Biology; Apoptosis; Lewis lung carcinoma; Flow cytometry; Immunology; Medicine; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007459897,0.0003560163,0.0001992912,0.0001631777,0.0000987567,0.0002193776,0.0001429618,0.0001928978,0.002198865],"category_scores_gemma":[0.00004753106,0.00009154244,0.000238346,0.0001177828,0.0001706712,0.0001377318,0.0001119681,0.0005067441,0.000664911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426436,"about_ca_system_score_gemma":0.0001529256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004294841,"about_ca_topic_score_gemma":0.0003907536,"domain_scores_codex":[0.9999328,0.000009328608,0.000006006792,0.00001309933,0.00001742489,0.00002147276],"domain_scores_gemma":[0.9999491,0.000007898483,0.0000152204,0.000004678732,0.000006186125,0.00001686699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002026723,0.00001889937,0.0001068719,0.00002810421,0.000002211925,0.00002755166,0.000003292928,0.00002794324,0.999109,0.00002272625,0.00002120875,0.0004293982],"study_design_scores_gemma":[0.00003658547,0.0004835702,0.003613184,0.000005841066,0.00001239963,0.000172906,0.00002213298,0.0005036424,0.9940545,0.00002897703,0.0010635,0.000002710577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940709,0.001957624,0.001876839,0.0001316967,0.00004701635,0.00002299911,0.0004726336,0.00006152438,0.001358694],"genre_scores_gemma":[0.993654,0.0007245353,0.001530729,0.00006502424,0.00001616455,0.00002628964,0.0006456253,0.000009746806,0.003327959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198865,"threshold_uncertainty_score":0.007355988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04529363112813916,"score_gpt":0.3324614265401341,"score_spread":0.2871677954119949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}