{"id":"W2084124315","doi":"10.1139/o05-173","title":"ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2","year":2006,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Cancer cell; Cancer; Transfection; Downregulation and upregulation; Apoptosis; Glutathione; Cancer research; Molecular biology; Intracellular; Multiple drug resistance; Gene; Drug resistance; Cell biology; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460855,0.0001512121,0.000214493,0.0000300003,0.00003156513,0.000005222154,0.0001242617,0.0002661297,0.00001790845],"category_scores_gemma":[0.0000313183,0.0001360948,0.00004705997,0.00011568,0.0002536304,0.00000179796,0.0001300831,0.00006758259,4.696059e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006572236,"about_ca_system_score_gemma":0.0000404754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000950563,"about_ca_topic_score_gemma":0.000009877912,"domain_scores_codex":[0.998989,0.00004985766,0.0002571569,0.0003982827,0.00007813634,0.000227545],"domain_scores_gemma":[0.9994512,0.00002412785,0.0001227369,0.0002080265,0.0000952913,0.00009858627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000142022,0.00005032534,0.0006738276,0.0001641225,0.00001892901,3.10445e-7,0.000006739134,0.0000014703,0.9944844,0.00002094414,0.003527246,0.0009097256],"study_design_scores_gemma":[0.000353066,0.0001138677,0.0005040249,0.0000175232,0.00001749686,0.000001540564,0.00001445947,0.000004284207,0.9884947,0.00008743245,0.0102521,0.0001395431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847216,0.01359844,0.0002482304,0.0001582821,0.00002557449,0.0001173024,0.0001992239,0.000004208556,0.0009271267],"genre_scores_gemma":[0.995505,0.001449052,0.0008222034,0.00004430584,0.0000727954,0.00001854434,0.0002272497,0.00001134795,0.001849472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01214938,"threshold_uncertainty_score":0.5549786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005087789765603288,"score_gpt":0.2454982060857027,"score_spread":0.2404104163200994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}