{"id":"W2084214818","doi":"10.1038/ncomms5039","title":"Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health; Alberta Health Services; Hospital for Sick Children","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Drosha; microRNA; Biology; Mutation; Germline mutation; Downregulation and upregulation; Gene; Genetics; Cancer research; RNA interference; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646957,0.00008323609,0.00008968565,0.00008191528,0.00005446393,0.00001252067,0.0003923624,0.0002684957,0.000003628932],"category_scores_gemma":[0.00009407439,0.00007387738,0.00002623533,0.0001973337,0.00005319634,0.000003869921,0.000111622,0.0004621855,0.000007466893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002852017,"about_ca_system_score_gemma":0.00003996396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003045194,"about_ca_topic_score_gemma":0.002765597,"domain_scores_codex":[0.999395,0.0001305291,0.0001453765,0.0001453188,0.00006161899,0.0001221546],"domain_scores_gemma":[0.9993647,0.0000247616,0.00007290893,0.0004708689,0.00003988513,0.00002681962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003358029,0.0002324435,0.003957369,0.0000480331,0.00002745303,0.000001199889,0.000561094,0.00008801388,0.9664007,0.0008052849,0.001907492,0.02593727],"study_design_scores_gemma":[0.003019962,0.000621655,0.1358269,0.0008456968,0.00004897133,0.00004745171,0.0009191315,0.004308795,0.7161143,0.001635433,0.1356316,0.0009800051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853587,0.008201272,0.00001335098,0.003667981,0.0001232529,0.0002224553,0.000008636502,0.000010032,0.002394304],"genre_scores_gemma":[0.9968764,0.001553737,0.0007782487,0.0002495564,0.00004139385,0.00008400458,0.0003191773,0.000009263214,0.00008825772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2502864,"threshold_uncertainty_score":0.3012632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015537771592007,"score_gpt":0.2789562866021073,"score_spread":0.2688009088861872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}