{"id":"W2084214818","doi":"10.1038/ncomms5039","title":"Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health; Alberta Health Services; Hospital for Sick Children","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Drosha; microRNA; Biology; Mutation; Germline mutation; Downregulation and upregulation; Gene; Genetics; Cancer research; RNA interference; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008403986,0.0001541833,0.0001849217,0.0003100315,0.00008550959,0.0002592754,0.00008211172,0.0002312541,0.001234466],"category_scores_gemma":[0.0002989241,0.0001381862,0.0002468096,0.0001397444,0.0001384546,0.00008149554,0.0001568679,0.0002221771,0.0004477303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001242477,"about_ca_system_score_gemma":0.00008142237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001348299,"about_ca_topic_score_gemma":0.0001667955,"domain_scores_codex":[0.9998796,0.00001517323,0.00001622911,0.00003205342,0.00003587868,0.00002104008],"domain_scores_gemma":[0.9997895,0.00004376817,0.00007609768,0.00002173372,0.0000183631,0.00005061006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008326145,0.00001107229,0.0036668,0.00001371906,0.00001615526,0.0008013433,0.00001521228,0.00006025493,0.9936169,0.0000375606,0.00007122517,0.001606459],"study_design_scores_gemma":[0.00002800304,0.0004564957,0.1320799,0.000008447878,0.00005973827,0.01199483,0.00007346525,0.001709946,0.8508111,0.0001739363,0.002587964,0.00001616012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983474,0.000286715,0.0006866069,0.00002270356,0.00001288044,0.000006150319,0.0001986977,0.00005416161,0.0003846304],"genre_scores_gemma":[0.9986328,0.0001586165,0.0004352015,0.00001902622,0.000006207191,0.000005338772,0.0002514991,0.00001578536,0.0004754259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001234466,"threshold_uncertainty_score":0.004129708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015537771592007,"score_gpt":0.2789562866021073,"score_spread":0.2688009088861872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}