{"id":"W2084257941","doi":"10.1002/1099-0461(2000)14:5<262::aid-jbt5>3.0.co;2-2","title":"Transitory metabolic disruption and cytotoxicity elicited by benzo&lt;&amp;lsqb;&gt;a&lt;&amp;rsqb;&gt;pyrene in two cell lines from rainbow trout liver","year":2000,"lang":"en","type":"article","venue":"Journal of Biochemical and Molecular Toxicology","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"U.S. Environmental Protection Agency","keywords":"Benzo(a)pyrene; Cytotoxicity; Geldanamycin; Chemistry; Viability assay; Cell culture; Biochemistry; Hepatocyte; Rainbow trout; Molecular biology; Cell; Carcinogen; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003909851,0.0003915252,0.0007253662,0.0001319883,0.0001415289,0.0000300189,0.0003017127,0.0005478762,0.002885778],"category_scores_gemma":[0.0000527225,0.0003595011,0.0001751727,0.0002363437,0.0008245634,0.0002024394,0.0001266477,0.0006211216,0.00006864259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287502,"about_ca_system_score_gemma":0.00001745076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006881859,"about_ca_topic_score_gemma":0.0003556742,"domain_scores_codex":[0.9974025,0.0003672408,0.0007740956,0.0005956518,0.0002837199,0.0005767714],"domain_scores_gemma":[0.9989146,0.0001661127,0.0002777732,0.0002314096,0.00001068033,0.000399452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004212468,0.0007643815,0.005033466,0.00001024308,0.00005599799,0.0000972543,0.0002798123,0.0001520561,0.9884111,0.000008745399,0.001489985,0.003275689],"study_design_scores_gemma":[0.004340078,0.0005844775,0.03144643,0.00003069409,0.0002088041,0.000382235,0.00003127733,0.000281342,0.9223837,0.0008865375,0.03881786,0.0006065932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922875,0.005813689,0.0002843547,0.0006476125,0.0001183905,0.0002642657,0.00004855558,0.00001561482,0.0005200573],"genre_scores_gemma":[0.9919833,0.003307429,0.002155871,0.001909786,0.0001284435,0.00001696348,0.00004573208,0.00003008809,0.0004223837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06602746,"threshold_uncertainty_score":0.9998857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006439198688581043,"score_gpt":0.226206696399322,"score_spread":0.219767497710741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}