{"id":"W2084259712","doi":"10.1182/blood-2014-10-609370","title":"Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; University of Pennsylvania","keywords":"Wnt signaling pathway; Stem cell; Leukemia; Cancer research; Biology; Cell biology; Chemistry; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064124,0.00008774282,0.00008725133,0.00003020313,0.00001449724,0.00001168061,0.00005440864,0.0001419948,0.00000256651],"category_scores_gemma":[0.000007955772,0.00009153269,0.00002278936,0.00005429212,0.00002557979,0.000005070011,0.0000527613,0.00006126743,0.00000429545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000515775,"about_ca_system_score_gemma":0.0001168348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000349464,"about_ca_topic_score_gemma":0.00005368707,"domain_scores_codex":[0.9994014,0.00003348883,0.0001223712,0.0002264339,0.0000785099,0.0001377944],"domain_scores_gemma":[0.9997014,0.000005181966,0.00005248895,0.0001333198,0.00003788147,0.00006966971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000611923,0.00003364133,0.0004310119,0.000009476985,0.00003771826,0.000004391129,0.0001975294,0.0008012349,0.9949123,0.00001386566,0.0001943018,0.003303396],"study_design_scores_gemma":[0.001563649,0.0001404015,0.0004990741,0.00001771436,0.00002547657,0.00001215102,0.0001431602,0.0001018826,0.9929067,0.00007738324,0.004385993,0.0001264171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979846,0.001248115,0.00006954137,0.00004638536,0.00008232934,0.0001182428,0.000007196741,0.000008077107,0.0004355417],"genre_scores_gemma":[0.9991825,0.00007046616,0.0001647848,0.00003842733,0.0001524399,0.000007766335,0.00002184108,0.00001396695,0.0003478464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004191692,"threshold_uncertainty_score":0.3732595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02049243326178527,"score_gpt":0.2446825696259021,"score_spread":0.2241901363641169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}