{"id":"W2084259712","doi":"10.1182/blood-2014-10-609370","title":"Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; University of Pennsylvania","keywords":"Wnt signaling pathway; Stem cell; Leukemia; Cancer research; Biology; Cell biology; Chemistry; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008417943,0.0001823367,0.0002056459,0.0001838803,0.0001616908,0.0003599408,0.00009894144,0.0001838324,0.001166877],"category_scores_gemma":[0.0000832495,0.0000988774,0.0001902496,0.0001862913,0.0002141557,0.0001838084,0.0001773777,0.0003410542,0.0005118059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003221885,"about_ca_system_score_gemma":0.0001951696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006898587,"about_ca_topic_score_gemma":0.0009780132,"domain_scores_codex":[0.9999087,0.00001357545,0.000009410283,0.0000150632,0.00002862601,0.00002468446],"domain_scores_gemma":[0.9999375,0.0000059317,0.00002237938,0.000006575895,0.000006234357,0.00002138254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008199234,0.00001748874,0.0007362293,0.00001396859,0.000002669753,0.000106279,0.00001724637,0.0000419139,0.9969627,0.0003022819,0.00003656444,0.001680597],"study_design_scores_gemma":[0.00002295548,0.0002690165,0.02103437,0.000008911709,0.00001909547,0.001515241,0.00008588795,0.0006475133,0.969344,0.0002910458,0.006757299,0.000004571707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919983,0.001099672,0.003780002,0.0001238366,0.0000134131,0.00003636745,0.0004438299,0.0001535227,0.002351131],"genre_scores_gemma":[0.9951686,0.0005561826,0.001283619,0.00004654741,0.000005123916,0.00002485004,0.000674328,0.00001677103,0.002224131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166877,"threshold_uncertainty_score":0.003903627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02049243326178527,"score_gpt":0.2446825696259021,"score_spread":0.2241901363641169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}