{"id":"W2084283183","doi":"10.1021/jm401836p","title":"Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"NS5A; Daclatasvir; Replicon; Chemistry; Potency; Virology; Hepatitis C virus; Pharmacology; NS3; Protease inhibitor (pharmacology); Drug discovery; Hepacivirus; Virus; Biochemistry; Biology; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001705867,0.0001392257,0.0004735389,0.00006601509,0.00006367272,0.00001949025,0.000325779,0.000111016,0.0002727055],"category_scores_gemma":[0.00250751,0.00008720227,0.0001766065,0.0002221529,0.0003387296,0.0001529157,0.00006816418,0.0006861169,0.00000821619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001395178,"about_ca_system_score_gemma":0.0002919634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002927247,"about_ca_topic_score_gemma":0.00001714082,"domain_scores_codex":[0.9974012,0.00009263547,0.0008527063,0.0001768293,0.001257443,0.0002191828],"domain_scores_gemma":[0.9976904,0.0003266929,0.0006442993,0.0006635124,0.0004690054,0.0002060843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003524454,0.0001809425,0.04596785,0.000420565,0.0001280264,0.00006839547,0.0002076172,0.000004055875,0.8971753,0.00003743706,0.02879489,0.02666251],"study_design_scores_gemma":[0.002876452,0.0009515627,0.08671767,0.001340773,0.0002734818,0.001210904,0.0002440538,0.0007129234,0.8046477,0.0003262834,0.1005124,0.0001858305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839767,0.0005125665,0.0008613011,0.004766778,0.0001176172,0.0001404077,0.00002034732,0.000009211965,0.009595037],"genre_scores_gemma":[0.9963437,0.0008976093,0.0003197303,0.0003993312,0.001551818,0.000004047718,0.00002370898,0.00001996031,0.000440068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09252758,"threshold_uncertainty_score":0.3556005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153504786393423,"score_gpt":0.3288885122306581,"score_spread":0.2973534643667238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}