{"id":"W2084283183","doi":"10.1021/jm401836p","title":"Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"NS5A; Daclatasvir; Replicon; Chemistry; Potency; Virology; Hepatitis C virus; Pharmacology; NS3; Protease inhibitor (pharmacology); Drug discovery; Hepacivirus; Virus; Biochemistry; Biology; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002970276,0.0003476728,0.0002230579,0.0004053612,0.000119624,0.0003269229,0.0001846843,0.0002384503,0.0006918187],"category_scores_gemma":[0.0001881792,0.0001410935,0.0001347086,0.0002381297,0.0002168015,0.000265019,0.0002076731,0.0004440966,0.000189793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004232873,"about_ca_system_score_gemma":0.000326396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006770265,"about_ca_topic_score_gemma":0.001435166,"domain_scores_codex":[0.9999205,0.00001873577,0.000004508436,0.00001326889,0.00002401109,0.00001905926],"domain_scores_gemma":[0.9999547,0.000004678643,0.000008691571,0.000002660989,0.00001197811,0.00001736191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008467167,0.0002957418,0.001230279,0.0004907124,0.00004570256,0.0004658903,0.0001102291,0.002394585,0.745226,0.006716455,0.001937913,0.2402398],"study_design_scores_gemma":[0.0007465468,0.005949823,0.009184176,0.0001309925,0.0001376645,0.00257875,0.00004997222,0.01360671,0.7895262,0.00205969,0.1759442,0.00008528959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7967702,0.1402104,0.03456664,0.002292134,0.0002992215,0.0003851641,0.001155484,0.0005074352,0.02381329],"genre_scores_gemma":[0.9322096,0.04738681,0.01399193,0.0004575528,0.0001406309,0.00006557674,0.0004880312,0.00002424989,0.005235663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006918187,"threshold_uncertainty_score":0.003071129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153504786393423,"score_gpt":0.3288885122306581,"score_spread":0.2973534643667238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}