{"id":"W2084295601","doi":"10.1038/nchembio.1412","title":"E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Institute for Research in Immunology and Cancer; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; National Center for Research Resources; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Ubiquitin; Ubiquitin-conjugating enzyme; Ubiquitin ligase; Deubiquitinating enzyme; Enzyme; Protein subunit; Ternary complex; Biochemistry; Chemistry; Small molecule; Proteasome; Ubiquitins; Ubiquitin-Protein Ligases; Cell biology; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863543,0.0005195408,0.0004341305,0.0001769183,0.0003085478,0.0007506451,0.0007567797,0.0004591962,0.002521816],"category_scores_gemma":[0.0003192977,0.0002559557,0.0003920375,0.0001840869,0.0003930797,0.0004614655,0.0004862869,0.0008158439,0.0007245803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006709149,"about_ca_system_score_gemma":0.0002597314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007496165,"about_ca_topic_score_gemma":0.0007708061,"domain_scores_codex":[0.9997296,0.00003591178,0.00003153075,0.00005763905,0.00005454575,0.00009065984],"domain_scores_gemma":[0.9998688,0.00003154001,0.00002830481,0.00002481033,0.00001610107,0.00003054433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004769127,0.0001269457,0.0001764727,0.00003964954,0.00002316454,0.00007685574,0.00001677428,0.000310007,0.9962335,0.0004766885,0.0001829626,0.001860038],"study_design_scores_gemma":[0.00002995836,0.00006134283,0.0002407744,0.000001760868,0.000006419652,0.0000690146,0.000005354819,0.001169605,0.9975603,0.00003499819,0.0008162298,0.000004175718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924797,0.0006580544,0.004546373,0.0001702158,0.00004968693,0.0000262119,0.0001119913,0.000205369,0.001752488],"genre_scores_gemma":[0.9969338,0.0001759779,0.001130046,0.00006952069,0.00001018813,0.00001775735,0.0001624761,0.00003587671,0.001464285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002521816,"threshold_uncertainty_score":0.008436322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004432096238254004,"score_gpt":0.2314505090309411,"score_spread":0.2270184127926871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}