{"id":"W2084295601","doi":"10.1038/nchembio.1412","title":"E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Institute for Research in Immunology and Cancer; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; National Center for Research Resources; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Ubiquitin; Ubiquitin-conjugating enzyme; Ubiquitin ligase; Deubiquitinating enzyme; Enzyme; Protein subunit; Ternary complex; Biochemistry; Chemistry; Small molecule; Proteasome; Ubiquitins; Ubiquitin-Protein Ligases; Cell biology; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009320988,0.0001622962,0.0001824401,0.00002539057,0.00002281403,0.000008468262,0.0001380426,0.0007388846,0.0001747791],"category_scores_gemma":[0.0001783113,0.0001267514,0.00005030278,0.00009966626,0.0001946241,0.00000540069,0.0000975592,0.0003075188,0.00001460464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001453971,"about_ca_system_score_gemma":0.0000383626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000118306,"about_ca_topic_score_gemma":0.000004239622,"domain_scores_codex":[0.9990786,0.0000683535,0.0002081939,0.0003482205,0.00007147618,0.0002250966],"domain_scores_gemma":[0.9993651,0.00002900835,0.0001153868,0.0002245761,0.0001916562,0.00007427987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001061086,0.00008440646,0.000409439,0.00004175029,0.00001920982,1.942454e-7,0.00002241513,8.039037e-7,0.994783,0.0001407888,0.003195397,0.001196448],"study_design_scores_gemma":[0.0004875059,0.0003559788,0.00003563822,0.00002590792,0.000006387885,0.000008464285,0.00002501146,0.00001306648,0.9931349,0.0003241287,0.005423557,0.0001594176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956852,0.0009557328,0.001714337,0.0002583792,0.00004954531,0.0002939112,0.00008878214,0.0000205528,0.0009336181],"genre_scores_gemma":[0.9977956,0.00003909692,0.0006482815,0.0004130101,0.0001044916,0.00005351435,0.0008676137,0.00001660956,0.00006172554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002228159,"threshold_uncertainty_score":0.5698954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004432096238254004,"score_gpt":0.2314505090309411,"score_spread":0.2270184127926871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}