{"id":"W2084308467","doi":"10.1126/scitranslmed.3001922","title":"Uroporphyrinogen Decarboxylase Is a Radiosensitizing Target for Head and Neck Cancer","year":2011,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Head and neck cancer; Head and neck; Medicine; Radiation therapy; Cancer research; Uroporphyrinogen III decarboxylase; Oncology; Internal medicine; Chemistry; Enzyme; Surgery; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427779,0.0002569474,0.0002939378,0.0002597276,0.0001780354,0.0002991009,0.0001353254,0.0002185104,0.0006709155],"category_scores_gemma":[0.000107414,0.0001119313,0.0002101604,0.0002359043,0.000159393,0.000109442,0.0002213885,0.0003928746,0.0001943315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005692607,"about_ca_system_score_gemma":0.0003758522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009223475,"about_ca_topic_score_gemma":0.00158632,"domain_scores_codex":[0.9999096,0.0000122634,0.000006497528,0.00002860426,0.00002691713,0.00001601465],"domain_scores_gemma":[0.9999613,0.000005667213,0.0000111412,0.000004991725,0.000009180661,0.000007857655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001864839,0.00004164523,0.001282363,0.0005062393,0.00002804097,0.0001499311,0.0000225603,0.0004268786,0.9577149,0.000291085,0.0007094534,0.0386405],"study_design_scores_gemma":[0.00003746308,0.0005813609,0.01271326,0.00005559288,0.000102289,0.001267445,0.00004172205,0.001695246,0.9345551,0.0002441549,0.04868674,0.00001963857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7878694,0.1803668,0.01909244,0.001510716,0.0003212093,0.0002243562,0.001281176,0.0004962891,0.008837583],"genre_scores_gemma":[0.9550558,0.03406234,0.005874066,0.0002877449,0.00004370879,0.00005561352,0.0009806387,0.00002664633,0.003613406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009223475,"threshold_uncertainty_score":0.004130244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03107182190845669,"score_gpt":0.3017295164399409,"score_spread":0.2706576945314842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}