{"id":"W2084318835","doi":"10.1016/s1074-7613(03)00032-3","title":"Granzyme B-Induced Apoptosis Requires Both Direct Caspase Activation and Relief of Caspase Inhibition","year":2003,"lang":"en","type":"article","venue":"Immunity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Alberta","funders":"","keywords":"Granzyme; Granzyme B; XIAP; Apoptosome; Caspase; Cell biology; Caspase 7; Biology; Cytotoxic T cell; Apoptosis; Granzyme A; Caspase 8; Inhibitor of apoptosis; Intrinsic apoptosis; Caspase 3; Caspase 10; Molecular biology; Programmed cell death; Biochemistry; Perforin; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341903,0.0001021464,0.0001116155,0.00004473667,0.0001158384,0.00001122057,0.00003274248,0.000134834,0.00001374638],"category_scores_gemma":[0.0001165007,0.00009633179,0.0000457354,0.00008166426,0.00003911175,0.000008751244,0.00003087329,0.00006543802,7.137091e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001189042,"about_ca_system_score_gemma":0.00002954465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003889466,"about_ca_topic_score_gemma":0.00004035504,"domain_scores_codex":[0.9993567,0.000131912,0.0001615248,0.0001585208,0.00008113667,0.0001101507],"domain_scores_gemma":[0.9995229,0.0000147595,0.0001031067,0.0002529355,0.00006548546,0.0000408242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004846877,0.0000714208,0.00008849493,0.00002112415,0.0000159949,4.293545e-7,0.00007404389,0.00001090122,0.9972371,0.0005179388,0.00007325295,0.001840834],"study_design_scores_gemma":[0.0004513403,0.0002284608,0.002478156,0.00002384798,0.00001691448,0.000007566409,0.00009186816,0.00001811101,0.9953414,0.0002920887,0.0009370826,0.0001131809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974278,0.0002121745,0.0006633854,0.00003797162,0.00007012479,0.0001404644,0.000006960331,0.000009487669,0.001431592],"genre_scores_gemma":[0.9991488,0.0002047423,0.0002790105,0.00003776947,0.00002994782,0.00000901433,0.0001086292,0.00001216994,0.0001699476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002389661,"threshold_uncertainty_score":0.3928296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380003293120374,"score_gpt":0.2392483179683318,"score_spread":0.225448285037128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}