{"id":"W2084318835","doi":"10.1016/s1074-7613(03)00032-3","title":"Granzyme B-Induced Apoptosis Requires Both Direct Caspase Activation and Relief of Caspase Inhibition","year":2003,"lang":"en","type":"article","venue":"Immunity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Alberta","funders":"","keywords":"Granzyme; Granzyme B; XIAP; Apoptosome; Caspase; Cell biology; Caspase 7; Biology; Cytotoxic T cell; Apoptosis; Granzyme A; Caspase 8; Inhibitor of apoptosis; Intrinsic apoptosis; Caspase 3; Caspase 10; Molecular biology; Programmed cell death; Biochemistry; Perforin; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004776917,0.0006293929,0.000550571,0.0004399302,0.0002305516,0.0008756079,0.0004357549,0.0006584342,0.002437164],"category_scores_gemma":[0.0004577785,0.0003697466,0.000523338,0.0002678092,0.0004343025,0.0008815764,0.0005949558,0.001873598,0.001274502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006172718,"about_ca_system_score_gemma":0.0002353067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000135267,"about_ca_topic_score_gemma":0.0002030319,"domain_scores_codex":[0.9995215,0.00007048598,0.0000583809,0.00007830637,0.000119259,0.0001520361],"domain_scores_gemma":[0.9995744,0.00007083285,0.0001141162,0.0001147801,0.00004928644,0.00007651593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005284151,0.00004803675,0.000171463,0.00006007831,0.00001413817,0.0001616902,0.00001385701,0.00009525756,0.9944976,0.0008434505,0.0000946884,0.003471427],"study_design_scores_gemma":[0.0001151045,0.0001581319,0.002534887,0.000005928101,0.000009916469,0.0009295773,0.00001934376,0.0005998142,0.9933873,0.0003357575,0.001898767,0.000005552342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570361,0.007435154,0.02590656,0.0007652031,0.000223261,0.0001388368,0.0005513052,0.0008348912,0.007108731],"genre_scores_gemma":[0.9894208,0.001034355,0.005169794,0.00009636595,0.00003820687,0.00006912382,0.0004290694,0.00004952293,0.003692726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002437164,"threshold_uncertainty_score":0.008153141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380003293120374,"score_gpt":0.2392483179683318,"score_spread":0.225448285037128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}