{"id":"W2084376878","doi":"10.4155/fmc.11.150","title":"Eukaryotic Initiation Factor 4F: A Vulnerability of Tumor Cells","year":2011,"lang":"en","type":"review","venue":"Future Medicinal Chemistry","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"EIF4E; EIF4G; Initiation factor; eIF4A; Eukaryotic initiation factor; EIF4A1; Biology; Eukaryotic translation; Cell biology; Eukaryotic translation initiation factor 4 gamma; eIF2; EIF4EBP1; Protein biosynthesis; Helicase; Integrated stress response; Translational regulation; Ribosome; Translation (biology); Messenger RNA; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878001,0.000581047,0.0006066961,0.0006751392,0.0002350038,0.0004653665,0.000365522,0.000602819,0.001919371],"category_scores_gemma":[0.0001301312,0.000152955,0.0001968186,0.0006155827,0.0002973911,0.0005231109,0.0003589152,0.0009319999,0.001829423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004862213,"about_ca_system_score_gemma":0.0004381166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005825037,"about_ca_topic_score_gemma":0.0009954078,"domain_scores_codex":[0.9999409,0.000007163158,0.000005303627,0.00001270506,0.00002455635,0.000009411825],"domain_scores_gemma":[0.9999592,0.00001168158,0.000007545995,0.000001752399,0.00001271681,0.000007049987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001058253,0.00005201742,0.0001946714,0.005914057,0.00004124401,0.0003645058,0.00005856814,0.0002766393,0.02335372,0.006106525,0.01885815,0.944674],"study_design_scores_gemma":[0.00001447472,0.00008777188,0.0006035014,0.000426584,0.0000335124,0.001644734,0.00002870122,0.00007446106,0.006238438,0.001608605,0.9892281,0.00001100431],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008827112,0.9945521,0.0005901284,0.0003759873,0.000188548,0.000006612024,0.00003309523,0.00001877163,0.00335199],"genre_scores_gemma":[0.005567134,0.9899253,0.0005118318,0.0002616044,0.0001494182,0.00001366488,0.00006728483,0.0000035312,0.003500151],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001919371,"threshold_uncertainty_score":0.00642091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248899692505438,"score_gpt":0.2985978888109291,"score_spread":0.2737079195603853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}